Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes
Objective: The aim of the study was to investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes. Methods: In this single-centre, retrospective cohort study 1081 women were screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4)...
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Bioscientifica
2023-10-01
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| Series: | European Thyroid Journal |
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| Online Access: | https://etj.bioscientifica.com/view/journals/etj/12/6/ETJ-23-0112.xml |
| _version_ | 1797652559230402560 |
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| author | Emna Jelloul Georgiana Sitoris Flora Veltri Pierre Kleynen Serge Rozenberg Kris G Poppe |
| author_facet | Emna Jelloul Georgiana Sitoris Flora Veltri Pierre Kleynen Serge Rozenberg Kris G Poppe |
| author_sort | Emna Jelloul |
| collection | DOAJ |
| description | Objective: The aim of the study was to investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes.
Methods: In this single-centre, retrospective cohort study 1081 women were screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4) and TPOAb. Exclusion criteria were twin- and assisted- reproduction pregnancies, women with TSH levels >3.74 mIU/L, severe hyperthyroidism, treated for thyroid dysfunction before or after screening and gestational blood sampling <6 or >16 weeks of pregnancy. The prevalence of adverse pregnancy outcomes was compared between the study group sTSH (TSH: < 0.06 mIU/L; n = 36) and euthyroid controls (TSH: 0.06–3.74 mIU/L; n = 1045), and the impact of sTSH on pregnancy outcomes verified in logistic regression analyses.
Results: Median (IQR) serum TSH level in women with sTSH was 0.03 (0.03 –0.03) vs 1.25 (0.81–1.82) mIU/L in controls and FT4 levels 18.0 (14.4–20.3) v s 14.2 (12.9–15.4) pmol/L; both P < 0.001. None of the women with sTSH had thyrotropin receptor antibodies. Compared with controls, the prevalence of TPOAb positivity (TAI) was comparable between groups (5.6% vs 6.6%; P = 0.803). The prevalence of maternal and neonatal pregnancy outcomes was comparable between the study and control group. The logistic regression analyses with corrections for TAI, FT4 and demographic parameters confirmed the absence of an association between sTSH, and the fo llowing outcomes: iron deficient anaemia (aORs (95% CI)): 1.41 (0.64-2.99); P = 0.385, gestational diabetes: 1.19 (0.44–2.88); P = 0.713, preterm birth: 1.57 (0.23–6.22); P = 0.574 and low Apgar-1′ score: 0.71 (0.11–2.67); P = 0.657.
Conclusions: Suppressed serum TSH levels during the first to early second tr imester of pregnancy were not associated with altered maternal or neonatal outcomes. |
| first_indexed | 2024-03-11T16:31:43Z |
| format | Article |
| id | doaj.art-db14b13d8eef439ab0cfe74392033e8c |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-03-11T16:31:43Z |
| publishDate | 2023-10-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-db14b13d8eef439ab0cfe74392033e8c2023-10-24T07:14:23ZengBioscientificaEuropean Thyroid Journal2235-08022023-10-0112618https://doi.org/10.1530/ETJ-23-0112Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomesEmna Jelloul0Georgiana Sitoris1Flora Veltri2Pierre Kleynen3Serge Rozenberg4Kris G Poppe5Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, BelgiumEndocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, BelgiumEndocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, BelgiumEndocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, BelgiumDepartement of Gynecology and Obstetrics, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, BelgiumEndocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, BelgiumObjective: The aim of the study was to investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes. Methods: In this single-centre, retrospective cohort study 1081 women were screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4) and TPOAb. Exclusion criteria were twin- and assisted- reproduction pregnancies, women with TSH levels >3.74 mIU/L, severe hyperthyroidism, treated for thyroid dysfunction before or after screening and gestational blood sampling <6 or >16 weeks of pregnancy. The prevalence of adverse pregnancy outcomes was compared between the study group sTSH (TSH: < 0.06 mIU/L; n = 36) and euthyroid controls (TSH: 0.06–3.74 mIU/L; n = 1045), and the impact of sTSH on pregnancy outcomes verified in logistic regression analyses. Results: Median (IQR) serum TSH level in women with sTSH was 0.03 (0.03 –0.03) vs 1.25 (0.81–1.82) mIU/L in controls and FT4 levels 18.0 (14.4–20.3) v s 14.2 (12.9–15.4) pmol/L; both P < 0.001. None of the women with sTSH had thyrotropin receptor antibodies. Compared with controls, the prevalence of TPOAb positivity (TAI) was comparable between groups (5.6% vs 6.6%; P = 0.803). The prevalence of maternal and neonatal pregnancy outcomes was comparable between the study and control group. The logistic regression analyses with corrections for TAI, FT4 and demographic parameters confirmed the absence of an association between sTSH, and the fo llowing outcomes: iron deficient anaemia (aORs (95% CI)): 1.41 (0.64-2.99); P = 0.385, gestational diabetes: 1.19 (0.44–2.88); P = 0.713, preterm birth: 1.57 (0.23–6.22); P = 0.574 and low Apgar-1′ score: 0.71 (0.11–2.67); P = 0.657. Conclusions: Suppressed serum TSH levels during the first to early second tr imester of pregnancy were not associated with altered maternal or neonatal outcomes.https://etj.bioscientifica.com/view/journals/etj/12/6/ETJ-23-0112.xmlpregnancyserum tshpregnancy outcomes |
| spellingShingle | Emna Jelloul Georgiana Sitoris Flora Veltri Pierre Kleynen Serge Rozenberg Kris G Poppe Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes European Thyroid Journal pregnancy serum tsh pregnancy outcomes |
| title | Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes |
| title_full | Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes |
| title_fullStr | Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes |
| title_full_unstemmed | Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes |
| title_short | Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes |
| title_sort | gestation suppressed serum tsh levels during early pregnancy are not associated with altered maternal and neonatal outcomes |
| topic | pregnancy serum tsh pregnancy outcomes |
| url | https://etj.bioscientifica.com/view/journals/etj/12/6/ETJ-23-0112.xml |
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