Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis
The aim of present work has been an assessment of degree of tubulointerstitial modifications of kidney parenchyma in patients with urolithiasis in different stages of surgical treatment using non-invasive mediators of nephrofibrosis and angiogenesis. The results of operations of 65 patients have bee...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Saratov State Medical University
2009-09-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/200903_428_433.pdf |
| _version_ | 1818568844201951232 |
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| author | N.B. Zakharova A.N. Ponukalin A.N. Rossolovskiy P.V. Glybochko G.N. Maslyakova A.M. Napsheva |
| author_facet | N.B. Zakharova A.N. Ponukalin A.N. Rossolovskiy P.V. Glybochko G.N. Maslyakova A.M. Napsheva |
| author_sort | N.B. Zakharova |
| collection | DOAJ |
| description | The aim of present work has been an assessment of degree of tubulointerstitial modifications of kidney parenchyma in patients with urolithiasis in different stages of surgical treatment using non-invasive mediators of nephrofibrosis and angiogenesis. The results of operations of 65 patients have been analysed. The content of nephrofibrosis molecular mediators in blood serum and urine has been determined. It has been shown that the most informative non-invasive mediators of tubulointerstitial fibrosis are IL12, VEGF in blood serum and b2-microglobulins MG, MCP 1 and NO excreted with urine. Patients with bilateral urolithiasis accompanied by expressive tubulointerstitial damages have had high indices of nephrofibrosis in postoperative period that can indicate irreversibility of these changes, leading to progression of chronic kidney disease |
| first_indexed | 2024-12-14T06:40:24Z |
| format | Article |
| id | doaj.art-db1643263a3a488d9dfa61929596a50a |
| institution | Directory Open Access Journal |
| issn | 1995-0039 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-14T06:40:24Z |
| publishDate | 2009-09-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-db1643263a3a488d9dfa61929596a50a2022-12-21T23:13:15ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182009-09-0153428433Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With UrolithiasisN.B. ZakharovaA.N. PonukalinA.N. RossolovskiyP.V. GlybochkoG.N. MaslyakovaA.M. NapshevaThe aim of present work has been an assessment of degree of tubulointerstitial modifications of kidney parenchyma in patients with urolithiasis in different stages of surgical treatment using non-invasive mediators of nephrofibrosis and angiogenesis. The results of operations of 65 patients have been analysed. The content of nephrofibrosis molecular mediators in blood serum and urine has been determined. It has been shown that the most informative non-invasive mediators of tubulointerstitial fibrosis are IL12, VEGF in blood serum and b2-microglobulins MG, MCP 1 and NO excreted with urine. Patients with bilateral urolithiasis accompanied by expressive tubulointerstitial damages have had high indices of nephrofibrosis in postoperative period that can indicate irreversibility of these changes, leading to progression of chronic kidney diseasehttp://www.ssmj.ru/system/files/200903_428_433.pdfmediators of nephrofibrosistubulointerstitial damagesurolithiasis |
| spellingShingle | N.B. Zakharova A.N. Ponukalin A.N. Rossolovskiy P.V. Glybochko G.N. Maslyakova A.M. Napsheva Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis Саратовский научно-медицинский журнал mediators of nephrofibrosis tubulointerstitial damages urolithiasis |
| title | Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis |
| title_full | Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis |
| title_fullStr | Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis |
| title_full_unstemmed | Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis |
| title_short | Profibrotic Mediators In Assessment Of Tubulointerstitial Changes In Surgical Treatment Of Patients With Urolithiasis |
| title_sort | profibrotic mediators in assessment of tubulointerstitial changes in surgical treatment of patients with urolithiasis |
| topic | mediators of nephrofibrosis tubulointerstitial damages urolithiasis |
| url | http://www.ssmj.ru/system/files/200903_428_433.pdf |
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