Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
Exosomes are endosomal-derived nanovesicles released by normal and tumor cells, which transfer functionally active proteins, lipids and nucleic acids between cells. They are important mediators of intercellular communication and act on the adjacent stroma as well as in the periphery. Recently, exoso...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2014-03-01
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Series: | Frontiers in Immunology |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00091/full |
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author | Katrin S. Reiners Juliane eDassler Christoph eCoch Elke ePogge Von Strandmann |
author_facet | Katrin S. Reiners Juliane eDassler Christoph eCoch Elke ePogge Von Strandmann |
author_sort | Katrin S. Reiners |
collection | DOAJ |
description | Exosomes are endosomal-derived nanovesicles released by normal and tumor cells, which transfer functionally active proteins, lipids and nucleic acids between cells. They are important mediators of intercellular communication and act on the adjacent stroma as well as in the periphery. Recently, exosomes have been recognized to play a pathophysiological role in various diseases such as cancer or infectious diseases. Tumor cell-derived exosomes (Tex) have been shown to act as tumor promotors by educating non-malignant cells to provide a tumor supporting microenvironment, which helps to circumvent immune detection by the host and supports metastasis. However, Tex with anti-tumor, immune-activating properties were also described reflecting the complexity of exosomes.<br/>Here, we assess the role of extracellular microvesicles/exosomes as messengers affecting NK cell function in health and disease and discuss the molecular basis for the differential impact of exosomes on NK cell activity. The molecular composition/load of exosomes and the mechanisms regulating their release remain unclear and need to be further analyzed to facilitate the development of new treatment options targeting the exosomal machinery.<br/> |
first_indexed | 2024-12-11T00:15:41Z |
format | Article |
id | doaj.art-db16a54a0ed04969bafd8f11cd05a34a |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-12-11T00:15:41Z |
publishDate | 2014-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-db16a54a0ed04969bafd8f11cd05a34a2022-12-22T01:27:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-03-01510.3389/fimmu.2014.0009180629Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.Katrin S. Reiners0Juliane eDassler1Christoph eCoch2Elke ePogge Von Strandmann3University Hospital CologneUniversity Hospital BonnUniversity Hospital BonnUniversity Hospital CologneExosomes are endosomal-derived nanovesicles released by normal and tumor cells, which transfer functionally active proteins, lipids and nucleic acids between cells. They are important mediators of intercellular communication and act on the adjacent stroma as well as in the periphery. Recently, exosomes have been recognized to play a pathophysiological role in various diseases such as cancer or infectious diseases. Tumor cell-derived exosomes (Tex) have been shown to act as tumor promotors by educating non-malignant cells to provide a tumor supporting microenvironment, which helps to circumvent immune detection by the host and supports metastasis. However, Tex with anti-tumor, immune-activating properties were also described reflecting the complexity of exosomes.<br/>Here, we assess the role of extracellular microvesicles/exosomes as messengers affecting NK cell function in health and disease and discuss the molecular basis for the differential impact of exosomes on NK cell activity. The molecular composition/load of exosomes and the mechanisms regulating their release remain unclear and need to be further analyzed to facilitate the development of new treatment options targeting the exosomal machinery.<br/>http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00091/fullExosomesMicrovesiclesNK cell regulationtumor derived vesiclesdendritic cell derived exosomes |
spellingShingle | Katrin S. Reiners Juliane eDassler Christoph eCoch Elke ePogge Von Strandmann Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity. Frontiers in Immunology Exosomes Microvesicles NK cell regulation tumor derived vesicles dendritic cell derived exosomes |
title | Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity. |
title_full | Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity. |
title_fullStr | Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity. |
title_full_unstemmed | Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity. |
title_short | Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity. |
title_sort | role of exosomes released by dendritic cells and or by tumor targets regulation of nk cell plasticity |
topic | Exosomes Microvesicles NK cell regulation tumor derived vesicles dendritic cell derived exosomes |
url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00091/full |
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