Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.

Exosomes are endosomal-derived nanovesicles released by normal and tumor cells, which transfer functionally active proteins, lipids and nucleic acids between cells. They are important mediators of intercellular communication and act on the adjacent stroma as well as in the periphery. Recently, exoso...

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Main Authors: Katrin S. Reiners, Juliane eDassler, Christoph eCoch, Elke ePogge Von Strandmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00091/full
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author Katrin S. Reiners
Juliane eDassler
Christoph eCoch
Elke ePogge Von Strandmann
author_facet Katrin S. Reiners
Juliane eDassler
Christoph eCoch
Elke ePogge Von Strandmann
author_sort Katrin S. Reiners
collection DOAJ
description Exosomes are endosomal-derived nanovesicles released by normal and tumor cells, which transfer functionally active proteins, lipids and nucleic acids between cells. They are important mediators of intercellular communication and act on the adjacent stroma as well as in the periphery. Recently, exosomes have been recognized to play a pathophysiological role in various diseases such as cancer or infectious diseases. Tumor cell-derived exosomes (Tex) have been shown to act as tumor promotors by educating non-malignant cells to provide a tumor supporting microenvironment, which helps to circumvent immune detection by the host and supports metastasis. However, Tex with anti-tumor, immune-activating properties were also described reflecting the complexity of exosomes.<br/>Here, we assess the role of extracellular microvesicles/exosomes as messengers affecting NK cell function in health and disease and discuss the molecular basis for the differential impact of exosomes on NK cell activity. The molecular composition/load of exosomes and the mechanisms regulating their release remain unclear and need to be further analyzed to facilitate the development of new treatment options targeting the exosomal machinery.<br/>
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spelling doaj.art-db16a54a0ed04969bafd8f11cd05a34a2022-12-22T01:27:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-03-01510.3389/fimmu.2014.0009180629Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.Katrin S. Reiners0Juliane eDassler1Christoph eCoch2Elke ePogge Von Strandmann3University Hospital CologneUniversity Hospital BonnUniversity Hospital BonnUniversity Hospital CologneExosomes are endosomal-derived nanovesicles released by normal and tumor cells, which transfer functionally active proteins, lipids and nucleic acids between cells. They are important mediators of intercellular communication and act on the adjacent stroma as well as in the periphery. Recently, exosomes have been recognized to play a pathophysiological role in various diseases such as cancer or infectious diseases. Tumor cell-derived exosomes (Tex) have been shown to act as tumor promotors by educating non-malignant cells to provide a tumor supporting microenvironment, which helps to circumvent immune detection by the host and supports metastasis. However, Tex with anti-tumor, immune-activating properties were also described reflecting the complexity of exosomes.<br/>Here, we assess the role of extracellular microvesicles/exosomes as messengers affecting NK cell function in health and disease and discuss the molecular basis for the differential impact of exosomes on NK cell activity. The molecular composition/load of exosomes and the mechanisms regulating their release remain unclear and need to be further analyzed to facilitate the development of new treatment options targeting the exosomal machinery.<br/>http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00091/fullExosomesMicrovesiclesNK cell regulationtumor derived vesiclesdendritic cell derived exosomes
spellingShingle Katrin S. Reiners
Juliane eDassler
Christoph eCoch
Elke ePogge Von Strandmann
Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
Frontiers in Immunology
Exosomes
Microvesicles
NK cell regulation
tumor derived vesicles
dendritic cell derived exosomes
title Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
title_full Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
title_fullStr Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
title_full_unstemmed Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
title_short Role of exosomes released by dendritic cells and/or by tumor targets: Regulation of NK cell plasticity.
title_sort role of exosomes released by dendritic cells and or by tumor targets regulation of nk cell plasticity
topic Exosomes
Microvesicles
NK cell regulation
tumor derived vesicles
dendritic cell derived exosomes
url http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00091/full
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AT christophecoch roleofexosomesreleasedbydendriticcellsandorbytumortargetsregulationofnkcellplasticity
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