HIV-1 release requires Nef-induced caspase activation.
HIV infection remains incurable to date and there are no compounds targeted at the viral release. We show here HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L. Blocking the caspases activation caused virion tethering by CD62L and...
Main Authors: | Jason Segura, Joanna Ireland, Zhongcheng Zou, Gwynne Roth, Julianna Buchwald, Thomas J Shen, Elizabeth Fischer, Susan Moir, Tae-Wook Chun, Peter D Sun |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0281087 |
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