A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

As human Tau undergoes pathologically relevant post-translational modifications when expressed in yeast, the use of humanized yeast models for the generation of novel Tau monoclonal antibodies has previously been proven to be successful. In this study, human Tau2N4R-ΔK280 purified from yeast was use...

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Bibliographic Details
Main Authors: Joke Verelst, Nick Geukens, Sabiha Eddarkaoui, Dorien Vliegen, Elien De Smidt, Joëlle Rosseels, Vanessa Franssens, Sofie Molenberghs, Cindy Francois, Erik Stoops, Maria Bjerke, Sebastiaan Engelborghs, Mohamed Laghmouchi, Sofie Carmans, Luc Buée, Eugeen Vanmechelen, Joris Winderickx, Debby Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
yeast
Saccharomyces cerevisiae
Tau
Tau isoforms
monoclonal antibodies
conformational differences
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00048/full

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