Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases
Background: Interstitial lung disease [ILD] is one of the most prevalent respiratory symptoms of connective tissue diseases [CTDs], leading to significant morbidity and death. Nailfold capillaroscopy [NFC] is the best tool for analysing microvascular disorders in CTDs since capillaroscopic alteratio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2022-07-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_261328_d0cf78bd4eb819d0ccaa8d58c90a65e6.pdf |
| _version_ | 1797364465157537792 |
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| author | Hytham Abd-Elmaksoud Kamal Darwish Mahmoud Abdelaty Awad Abas Waleed Abd-El-Naser |
| author_facet | Hytham Abd-Elmaksoud Kamal Darwish Mahmoud Abdelaty Awad Abas Waleed Abd-El-Naser |
| author_sort | Hytham Abd-Elmaksoud |
| collection | DOAJ |
| description | Background: Interstitial lung disease [ILD] is one of the most prevalent respiratory symptoms of connective tissue diseases [CTDs], leading to significant morbidity and death. Nailfold capillaroscopy [NFC] is the best tool for analysing microvascular disorders in CTDs since capillaroscopic alterations in the nailfold are well documented in several CTDs. The Aim of the work: To assess the value of Nailfold capillaroscopy examination in patients with ILD.Patients and methods: This study involved 100 patients aged between 18 and 90 years diagnosed with ILD divided into three groups; group [I] involved 30 patients with rheumatoid arthritis [RA] associated with ILD, group [II] involved 30 patients with systemic sclerosis [SSc] associated with ILD, and group [III] included 40 patients with idiopathic ILD. In all patients, NFC was performed with clinical and laboratory assessment.Results: According to nailfold capillaroscopic findings, patients with normal nailfold capillaroscopy were found only in idiopathic ILD. CTD-ILD group has a significantly lower mean capillary density than idiopathic ILD [p= <0.05]. Also, RA-ILD, IPF, and SSC-ILD subgroups had more severe abnormalities in capillaroscopy. The RA-ILD subgroup’s capillary density was significantly lower than that of the idiopathic ILD only group. Furthermore, we found that [SSc-ILD] group had the lowest significant capillary number [ranged from 4-9/mm] & the highest significant capillary width [ranged from 29-76/μm] and the shortest significant capillary length [ranged from 75-256/μm] in comparison to the other groups.Conclusion: We can conclude that SSc-ILD patients had more severe nailfold-capillaroscopic abnormalities than both RA-ILD and idiopathic ILD groups. Assessment of Nail should be considered during ILD examination for early detection of Nailfold abnormality to improve prognosis of the disease. |
| first_indexed | 2024-03-08T16:35:43Z |
| format | Article |
| id | doaj.art-db187011265645088053d10f6ddd0880 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:43Z |
| publishDate | 2022-07-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-db187011265645088053d10f6ddd08802024-01-05T19:39:15ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802022-07-01472522252710.21608/ijma.2022.160690.1508261328Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung DiseasesHytham Abd-Elmaksoud0Kamal Darwish1Mahmoud Abdelaty2Awad Abas3Waleed Abd-El-Naser4Department of Chest Diseases, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, EgyptDepartment of Chest Diseases, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, EgyptDepartment of Chest Diseases, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, EgyptDepartment of Rheumatology and Rehabilitation, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, EgyptDepartment of Internal Medicine, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, EgyptBackground: Interstitial lung disease [ILD] is one of the most prevalent respiratory symptoms of connective tissue diseases [CTDs], leading to significant morbidity and death. Nailfold capillaroscopy [NFC] is the best tool for analysing microvascular disorders in CTDs since capillaroscopic alterations in the nailfold are well documented in several CTDs. The Aim of the work: To assess the value of Nailfold capillaroscopy examination in patients with ILD.Patients and methods: This study involved 100 patients aged between 18 and 90 years diagnosed with ILD divided into three groups; group [I] involved 30 patients with rheumatoid arthritis [RA] associated with ILD, group [II] involved 30 patients with systemic sclerosis [SSc] associated with ILD, and group [III] included 40 patients with idiopathic ILD. In all patients, NFC was performed with clinical and laboratory assessment.Results: According to nailfold capillaroscopic findings, patients with normal nailfold capillaroscopy were found only in idiopathic ILD. CTD-ILD group has a significantly lower mean capillary density than idiopathic ILD [p= <0.05]. Also, RA-ILD, IPF, and SSC-ILD subgroups had more severe abnormalities in capillaroscopy. The RA-ILD subgroup’s capillary density was significantly lower than that of the idiopathic ILD only group. Furthermore, we found that [SSc-ILD] group had the lowest significant capillary number [ranged from 4-9/mm] & the highest significant capillary width [ranged from 29-76/μm] and the shortest significant capillary length [ranged from 75-256/μm] in comparison to the other groups.Conclusion: We can conclude that SSc-ILD patients had more severe nailfold-capillaroscopic abnormalities than both RA-ILD and idiopathic ILD groups. Assessment of Nail should be considered during ILD examination for early detection of Nailfold abnormality to improve prognosis of the disease.https://ijma.journals.ekb.eg/article_261328_d0cf78bd4eb819d0ccaa8d58c90a65e6.pdfnailfold capillaroscopyinterstitial lung diseasesconnective tissue diseases |
| spellingShingle | Hytham Abd-Elmaksoud Kamal Darwish Mahmoud Abdelaty Awad Abas Waleed Abd-El-Naser Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases International Journal of Medical Arts nailfold capillaroscopy interstitial lung diseases connective tissue diseases |
| title | Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases |
| title_full | Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases |
| title_fullStr | Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases |
| title_full_unstemmed | Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases |
| title_short | Study of the Role of Nailfold Capillaroscopy in the Evaluation of Patients with Interstitial Lung Diseases |
| title_sort | study of the role of nailfold capillaroscopy in the evaluation of patients with interstitial lung diseases |
| topic | nailfold capillaroscopy interstitial lung diseases connective tissue diseases |
| url | https://ijma.journals.ekb.eg/article_261328_d0cf78bd4eb819d0ccaa8d58c90a65e6.pdf |
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