Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis
Psoriatic arthritis (PsA) is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints, and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains challenging. We developed a need-based layer...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383520306912 |
| _version_ | 1819059489717878784 |
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| author | Kaiyue Yu Xiuming Yu Sisi Cao Yixuan Wang Yuanhao Zhai Fengdie Yang Xiaoyuan Yang Yi Lu Chuanbin Wu Yuehong Xu |
| author_facet | Kaiyue Yu Xiuming Yu Sisi Cao Yixuan Wang Yuanhao Zhai Fengdie Yang Xiaoyuan Yang Yi Lu Chuanbin Wu Yuehong Xu |
| author_sort | Kaiyue Yu |
| collection | DOAJ |
| description | Psoriatic arthritis (PsA) is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints, and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains challenging. We developed a need-based layered dissolving microneedle (MN) system loading immunosuppressant tacrolimus (TAC) and anti-inflammatory diclofenac (DIC) in different layers of MNs, i.e., TD-MN, which aims to specifically deliver TAC and DIC to skin and articular cavity, achieving simultaneous alleviation of psoriatic skin and arthritic joint lesions in PsA. In vitro and in vivo skin permeation demonstrated that the inter-layer retained TAC within the skin of ∼100 μm, while the tip-layer delivered DIC up to ∼300 μm into the articular cavity. TD-MN not only efficiently decreased the psoriasis area and severity index scores and recovered the thickened epidermis of imiquimod-induced psoriasis but also alleviated carrageenan/kaolin-induced arthritis even better than DIC injection through reducing joint swelling, muscle atrophy, and cartilage destruction. Importantly, TD-MN significantly inhibited the serum TNF-α and IL-17A in psoriatic and arthritic rats. The results support that this approach represents a promising alternative to multi-administration of different drugs for comorbidity, providing a convenient and effective strategy for meeting the requirements of PsA treatment. |
| first_indexed | 2024-12-21T14:11:55Z |
| format | Article |
| id | doaj.art-db1af32dd0d34f38afb71b951827436e |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-21T14:11:55Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-db1af32dd0d34f38afb71b951827436e2022-12-21T19:01:01ZengElsevierActa Pharmaceutica Sinica B2211-38352021-02-01112505519Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritisKaiyue Yu0Xiuming Yu1Sisi Cao2Yixuan Wang3Yuanhao Zhai4Fengdie Yang5Xiaoyuan Yang6Yi Lu7Chuanbin Wu8Yuehong Xu9School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaCorresponding author. Fax: +86 20 39943119.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaPsoriatic arthritis (PsA) is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints, and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains challenging. We developed a need-based layered dissolving microneedle (MN) system loading immunosuppressant tacrolimus (TAC) and anti-inflammatory diclofenac (DIC) in different layers of MNs, i.e., TD-MN, which aims to specifically deliver TAC and DIC to skin and articular cavity, achieving simultaneous alleviation of psoriatic skin and arthritic joint lesions in PsA. In vitro and in vivo skin permeation demonstrated that the inter-layer retained TAC within the skin of ∼100 μm, while the tip-layer delivered DIC up to ∼300 μm into the articular cavity. TD-MN not only efficiently decreased the psoriasis area and severity index scores and recovered the thickened epidermis of imiquimod-induced psoriasis but also alleviated carrageenan/kaolin-induced arthritis even better than DIC injection through reducing joint swelling, muscle atrophy, and cartilage destruction. Importantly, TD-MN significantly inhibited the serum TNF-α and IL-17A in psoriatic and arthritic rats. The results support that this approach represents a promising alternative to multi-administration of different drugs for comorbidity, providing a convenient and effective strategy for meeting the requirements of PsA treatment.http://www.sciencedirect.com/science/article/pii/S2211383520306912Layered microneedlesNeed-based drug deliveryTacrolimusDiclofenac sodiumPsoriasisPsoriatic arthritis |
| spellingShingle | Kaiyue Yu Xiuming Yu Sisi Cao Yixuan Wang Yuanhao Zhai Fengdie Yang Xiaoyuan Yang Yi Lu Chuanbin Wu Yuehong Xu Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis Acta Pharmaceutica Sinica B Layered microneedles Need-based drug delivery Tacrolimus Diclofenac sodium Psoriasis Psoriatic arthritis |
| title | Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis |
| title_full | Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis |
| title_fullStr | Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis |
| title_full_unstemmed | Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis |
| title_short | Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis |
| title_sort | layered dissolving microneedles as a need based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis |
| topic | Layered microneedles Need-based drug delivery Tacrolimus Diclofenac sodium Psoriasis Psoriatic arthritis |
| url | http://www.sciencedirect.com/science/article/pii/S2211383520306912 |
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