Embryonic ILC-poiesis across tissues
The family of innate lymphoid cells (ILCs), consisting of Group 1 ILCs (natural killer cells and ILC1), ILC2, and ILC3, are critical effectors of innate immunity, inflammation, and homeostasis post-natally, but also exert essential functions before birth. Recent studies during critical developmental...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1040624/full |
| _version_ | 1828162348852969472 |
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| author | Daniela Carolina Hernández-Torres Daniela Carolina Hernández-Torres Christina Stehle Christina Stehle |
| author_facet | Daniela Carolina Hernández-Torres Daniela Carolina Hernández-Torres Christina Stehle Christina Stehle |
| author_sort | Daniela Carolina Hernández-Torres |
| collection | DOAJ |
| description | The family of innate lymphoid cells (ILCs), consisting of Group 1 ILCs (natural killer cells and ILC1), ILC2, and ILC3, are critical effectors of innate immunity, inflammation, and homeostasis post-natally, but also exert essential functions before birth. Recent studies during critical developmental periods in the embryo have hinted at complex waves of tissue colonization, and highlighted the breadth of multipotent and committed ILC progenitors from both classic fetal hematopoietic organs such as the liver, as well as tissue sites such as the lung, thymus, and intestine. Assessment of the mechanisms driving cell fate and function of the ILC family in the embryo will be vital to the understanding ILC biology throughout fetal life and beyond. |
| first_indexed | 2024-04-12T00:54:03Z |
| format | Article |
| id | doaj.art-db1fb4c48bfb454f96e1e25419cce6bb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T00:54:03Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-db1fb4c48bfb454f96e1e25419cce6bb2022-12-22T03:54:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10406241040624Embryonic ILC-poiesis across tissuesDaniela Carolina Hernández-Torres0Daniela Carolina Hernández-Torres1Christina Stehle2Christina Stehle3Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, GermanyMedical Department I, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyInnate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Berlin, GermanyMedical Department I, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyThe family of innate lymphoid cells (ILCs), consisting of Group 1 ILCs (natural killer cells and ILC1), ILC2, and ILC3, are critical effectors of innate immunity, inflammation, and homeostasis post-natally, but also exert essential functions before birth. Recent studies during critical developmental periods in the embryo have hinted at complex waves of tissue colonization, and highlighted the breadth of multipotent and committed ILC progenitors from both classic fetal hematopoietic organs such as the liver, as well as tissue sites such as the lung, thymus, and intestine. Assessment of the mechanisms driving cell fate and function of the ILC family in the embryo will be vital to the understanding ILC biology throughout fetal life and beyond.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1040624/fullinnate lymphoid cells (ILCs)progenitors cellsembryonic developmentin situ differentiationprenatal immunity |
| spellingShingle | Daniela Carolina Hernández-Torres Daniela Carolina Hernández-Torres Christina Stehle Christina Stehle Embryonic ILC-poiesis across tissues Frontiers in Immunology innate lymphoid cells (ILCs) progenitors cells embryonic development in situ differentiation prenatal immunity |
| title | Embryonic ILC-poiesis across tissues |
| title_full | Embryonic ILC-poiesis across tissues |
| title_fullStr | Embryonic ILC-poiesis across tissues |
| title_full_unstemmed | Embryonic ILC-poiesis across tissues |
| title_short | Embryonic ILC-poiesis across tissues |
| title_sort | embryonic ilc poiesis across tissues |
| topic | innate lymphoid cells (ILCs) progenitors cells embryonic development in situ differentiation prenatal immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1040624/full |
| work_keys_str_mv | AT danielacarolinahernandeztorres embryonicilcpoiesisacrosstissues AT danielacarolinahernandeztorres embryonicilcpoiesisacrosstissues AT christinastehle embryonicilcpoiesisacrosstissues AT christinastehle embryonicilcpoiesisacrosstissues |