Human cytomegalovirus vaccine based on the envelope gH/gL pentamer complex.
Human Cytomegalovirus (HCMV) utilizes two different pathways for host cell entry. HCMV entry into fibroblasts requires glycoproteins gB and gH/gL, whereas HCMV entry into epithelial and endothelial cells (EC) requires an additional complex composed of gH, gL, UL128, UL130, and UL131A, referred to as...
المؤلفون الرئيسيون: | Felix Wussow, Flavia Chiuppesi, Joy Martinez, John Campo, Erica Johnson, Christin Flechsig, Maegan Newell, Elaine Tran, Jose Ortiz, Corinna La Rosa, Andreas Herrmann, Jeff Longmate, Rana Chakraborty, Peter A Barry, Don J Diamond |
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التنسيق: | مقال |
اللغة: | English |
منشور في: |
Public Library of Science (PLoS)
2014-11-01
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سلاسل: | PLoS Pathogens |
الوصول للمادة أونلاين: | http://europepmc.org/articles/PMC4239111?pdf=render |
مواد مشابهة
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Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.
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Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions.
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Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry.
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منشور في: (2017-04-01) -
Complete protection of mice against lethal murine cytomegalovirus challenge by immunization with DNA vaccines encoding envelope glycoprotein complex III antigens gH, gL and gO.
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منشور في: (2015-01-01) -
Comparison of homologous and heterologous prime-boost vaccine approaches using Modified Vaccinia Ankara and soluble protein to induce neutralizing antibodies by the human cytomegalovirus pentamer complex in mice.
حسب: Flavia Chiuppesi, وآخرون
منشور في: (2017-01-01)