Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices
Abstract To establish whether obesity involves activation of endogenous ciliary neurotrophic factor (CNTF) signalling, we evaluated its plasma levels in patients with obesity and correlated its values with the major clinical and haematological indices of obesity, insulin resistance and systemic infl...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11942-x |
| _version_ | 1811250938194690048 |
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| author | Jessica Perugini Eleonora Di Mercurio Angelica Giuliani Jacopo Sabbatinelli Anna Rita Bonfigli Elena Tortato Ilenia Severi Saverio Cinti Fabiola Olivieri Carel W. le Roux Rosaria Gesuita Antonio Giordano |
| author_facet | Jessica Perugini Eleonora Di Mercurio Angelica Giuliani Jacopo Sabbatinelli Anna Rita Bonfigli Elena Tortato Ilenia Severi Saverio Cinti Fabiola Olivieri Carel W. le Roux Rosaria Gesuita Antonio Giordano |
| author_sort | Jessica Perugini |
| collection | DOAJ |
| description | Abstract To establish whether obesity involves activation of endogenous ciliary neurotrophic factor (CNTF) signalling, we evaluated its plasma levels in patients with obesity and correlated its values with the major clinical and haematological indices of obesity, insulin resistance and systemic inflammation. This study involved 118 subjects: 39 healthy controls (19 men), 39 subjects with obesity (19 men) and 40 subjects with obesity and diabetes (20 men). Plasma CNTF and CNTF receptor α (CNTFRα) were measured using commercial ELISA kits. The results showed that plasma CNTF was significantly higher in males and females with obesity with and without diabetes than in healthy subjects. Women consistently exhibited higher levels of circulating CNTF. In both genders, CNTF levels correlated significantly and positively with obesity (BMI, WHR, leptin), diabetes (fasting insulin, HOMA index and HbA1c) and inflammation (IL-6 and hsCRP) indices. Circulating CNTFRα and the CNTF/CNTFRα molar ratio tended to be higher in the patient groups than in controls. In conclusion, endogenous CNTF signalling is activated in human obesity and may help counteract some adverse effects of obesity. Studies involving a higher number of selected patients may reveal circulating CNTF and/or CNTFRα as potential novel diagnostic and/or prognostic markers of obesity, diabetes and associated diseases. |
| first_indexed | 2024-04-12T16:12:15Z |
| format | Article |
| id | doaj.art-db21809674df46a5a7d6c8009e3ff0ae |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T16:12:15Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-db21809674df46a5a7d6c8009e3ff0ae2022-12-22T03:25:52ZengNature PortfolioScientific Reports2045-23222022-05-0112111210.1038/s41598-022-11942-xCiliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indicesJessica Perugini0Eleonora Di Mercurio1Angelica Giuliani2Jacopo Sabbatinelli3Anna Rita Bonfigli4Elena Tortato5Ilenia Severi6Saverio Cinti7Fabiola Olivieri8Carel W. le Roux9Rosaria Gesuita10Antonio Giordano11Department of Experimental and Clinical Medicine, School of Medicine, Marche Polytechnic UniversityDepartment of Experimental and Clinical Medicine, School of Medicine, Marche Polytechnic UniversityDepartment of Clinical and Molecular Sciences, Marche Polytechnic UniversityDepartment of Clinical and Molecular Sciences, Marche Polytechnic UniversityScientific Direction, IRCCS INRCADiabetology Unit, IRCCS INRCADepartment of Experimental and Clinical Medicine, School of Medicine, Marche Polytechnic UniversityDepartment of Experimental and Clinical Medicine, School of Medicine, Marche Polytechnic UniversityDepartment of Clinical and Molecular Sciences, Marche Polytechnic UniversityDiabetes Complications Research Centre, Conway Institute, School of Medicine, University College DublinCenter of Epidemiology and Biostatistics, Marche Polytechnic UniversityDepartment of Experimental and Clinical Medicine, School of Medicine, Marche Polytechnic UniversityAbstract To establish whether obesity involves activation of endogenous ciliary neurotrophic factor (CNTF) signalling, we evaluated its plasma levels in patients with obesity and correlated its values with the major clinical and haematological indices of obesity, insulin resistance and systemic inflammation. This study involved 118 subjects: 39 healthy controls (19 men), 39 subjects with obesity (19 men) and 40 subjects with obesity and diabetes (20 men). Plasma CNTF and CNTF receptor α (CNTFRα) were measured using commercial ELISA kits. The results showed that plasma CNTF was significantly higher in males and females with obesity with and without diabetes than in healthy subjects. Women consistently exhibited higher levels of circulating CNTF. In both genders, CNTF levels correlated significantly and positively with obesity (BMI, WHR, leptin), diabetes (fasting insulin, HOMA index and HbA1c) and inflammation (IL-6 and hsCRP) indices. Circulating CNTFRα and the CNTF/CNTFRα molar ratio tended to be higher in the patient groups than in controls. In conclusion, endogenous CNTF signalling is activated in human obesity and may help counteract some adverse effects of obesity. Studies involving a higher number of selected patients may reveal circulating CNTF and/or CNTFRα as potential novel diagnostic and/or prognostic markers of obesity, diabetes and associated diseases.https://doi.org/10.1038/s41598-022-11942-x |
| spellingShingle | Jessica Perugini Eleonora Di Mercurio Angelica Giuliani Jacopo Sabbatinelli Anna Rita Bonfigli Elena Tortato Ilenia Severi Saverio Cinti Fabiola Olivieri Carel W. le Roux Rosaria Gesuita Antonio Giordano Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices Scientific Reports |
| title | Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices |
| title_full | Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices |
| title_fullStr | Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices |
| title_full_unstemmed | Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices |
| title_short | Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices |
| title_sort | ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices |
| url | https://doi.org/10.1038/s41598-022-11942-x |
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