Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment
Objectives: This study aimed to explore the effects of 25-hydroxy vitamin D (25[OH]D) on T lymphocyte subsets and sputum smear conversion during antituberculosis (TB) treatment. Methods: A total of 120 newly diagnosed patients with active pulmonary TB were collected and classified into vitamin D suf...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222002569 |
| _version_ | 1817975865930153984 |
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| author | Haibo Yang Hongyu Chen Yingmei Ma Zhen Dong Mingde Ni Yuefu Lin Laiyin Zhang Donghao Zhou Qinghua Zhang |
| author_facet | Haibo Yang Hongyu Chen Yingmei Ma Zhen Dong Mingde Ni Yuefu Lin Laiyin Zhang Donghao Zhou Qinghua Zhang |
| author_sort | Haibo Yang |
| collection | DOAJ |
| description | Objectives: This study aimed to explore the effects of 25-hydroxy vitamin D (25[OH]D) on T lymphocyte subsets and sputum smear conversion during antituberculosis (TB) treatment. Methods: A total of 120 newly diagnosed patients with active pulmonary TB were collected and classified into vitamin D sufficiency group, vitamin D insufficiency group, and vitamin D deficiency group according to serum 25(OH)D levels. The clinical data and sputum smear conversion were collected and serum 25(OH)D and T lymphocyte subsets were also measured and compared. Results: Our data showed that 25(OH)D levels reached the lowest point at two months of anti-TB treatment. Significant differences existed in the increase of CD4+ and CD8+ T cells on the basis of vitamin D levels. The vitamin D sufficiency group had a significantly higher increase of CD4+ T cells during six months of anti-TB treatment and CD8+ T cells after four months of anti-TB treatment than the other groups. Vitamin D had no effect on the time-to-sputum smear conversion (vitamin D sufficiency group: adjusted hazard ratio: 1.27, 95% confidence interval [CI]: 0.78–2.06); vitamin D insufficiency group: adjusted hazard ratio: 1.05, 95% CI: 0.63–1.75)]. Conclusion: Through null effects on sputum smear conversion, vitamin D may have a beneficial effect on the increase of CD4+ and CD8+ T cells during anti-TB treatment. |
| first_indexed | 2024-04-13T21:55:56Z |
| format | Article |
| id | doaj.art-db22bd0d0ee34dda9f97368d87409636 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-13T21:55:56Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-db22bd0d0ee34dda9f97368d874096362022-12-22T02:28:16ZengElsevierInternational Journal of Infectious Diseases1201-97122022-08-011211723Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatmentHaibo Yang0Hongyu Chen1Yingmei Ma2Zhen Dong3Mingde Ni4Yuefu Lin5Laiyin Zhang6Donghao Zhou7Qinghua Zhang8Department of Occupational Disease, Linyi People's Hospital, Linyi, ChinaDean's Office, Linyi People's Hospital, Linyi, ChinaDepartment of Infection Management, Linyi People's Hospital, Linyi, ChinaDepartment of Prevention, Linyi People's Hospital, Linyi, ChinaDepartment of Tuberculosis, Linyi People's Hospital, Linyi, ChinaDepartment of Prevention, Linyi People's Hospital, Linyi, ChinaDean's Office, Linyi People's Hospital, Linyi, ChinaDepartment of Clinical Nutrition, Linyi People's Hospital, Linyi, China; Corresponding authors.Dean's Office, Linyi People's Hospital, Linyi, China; Corresponding authors.Objectives: This study aimed to explore the effects of 25-hydroxy vitamin D (25[OH]D) on T lymphocyte subsets and sputum smear conversion during antituberculosis (TB) treatment. Methods: A total of 120 newly diagnosed patients with active pulmonary TB were collected and classified into vitamin D sufficiency group, vitamin D insufficiency group, and vitamin D deficiency group according to serum 25(OH)D levels. The clinical data and sputum smear conversion were collected and serum 25(OH)D and T lymphocyte subsets were also measured and compared. Results: Our data showed that 25(OH)D levels reached the lowest point at two months of anti-TB treatment. Significant differences existed in the increase of CD4+ and CD8+ T cells on the basis of vitamin D levels. The vitamin D sufficiency group had a significantly higher increase of CD4+ T cells during six months of anti-TB treatment and CD8+ T cells after four months of anti-TB treatment than the other groups. Vitamin D had no effect on the time-to-sputum smear conversion (vitamin D sufficiency group: adjusted hazard ratio: 1.27, 95% confidence interval [CI]: 0.78–2.06); vitamin D insufficiency group: adjusted hazard ratio: 1.05, 95% CI: 0.63–1.75)]. Conclusion: Through null effects on sputum smear conversion, vitamin D may have a beneficial effect on the increase of CD4+ and CD8+ T cells during anti-TB treatment.http://www.sciencedirect.com/science/article/pii/S120197122200256925-Hydroxy vitamin DT lymphocyte subsetsSputum smear conversionAntituberculosis treatment |
| spellingShingle | Haibo Yang Hongyu Chen Yingmei Ma Zhen Dong Mingde Ni Yuefu Lin Laiyin Zhang Donghao Zhou Qinghua Zhang Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment International Journal of Infectious Diseases 25-Hydroxy vitamin D T lymphocyte subsets Sputum smear conversion Antituberculosis treatment |
| title | Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment |
| title_full | Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment |
| title_fullStr | Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment |
| title_full_unstemmed | Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment |
| title_short | Effects of 25-hydroxy vitamin D on T lymphocyte subsets and sputum smear conversion during antituberculosis treatment |
| title_sort | effects of 25 hydroxy vitamin d on t lymphocyte subsets and sputum smear conversion during antituberculosis treatment |
| topic | 25-Hydroxy vitamin D T lymphocyte subsets Sputum smear conversion Antituberculosis treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222002569 |
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