Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging
Diagnostic tools for the early detection of renal injury caused by hyperuricemia are still lacking. Here, we investigated whether contrast-enhanced ultrasound (CEUS) could be used as a diagnostic tool for hyperuricemic nephropathy (HN). In the HN rat model, CEUS detected a significant decline in ren...
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2022-07-01
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| Series: | Disease Models & Mechanisms |
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| Online Access: | http://dmm.biologists.org/content/15/7/dmm049382 |
| _version_ | 1811214899780517888 |
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| author | Li He Ze Li Qunzi Zhang Yini Chen Yihui Gao Teng Chen Niansong Wang Lixin Jiang Ying Fan |
| author_facet | Li He Ze Li Qunzi Zhang Yini Chen Yihui Gao Teng Chen Niansong Wang Lixin Jiang Ying Fan |
| author_sort | Li He |
| collection | DOAJ |
| description | Diagnostic tools for the early detection of renal injury caused by hyperuricemia are still lacking. Here, we investigated whether contrast-enhanced ultrasound (CEUS) could be used as a diagnostic tool for hyperuricemic nephropathy (HN). In the HN rat model, CEUS detected a significant decline in renal cortical perfusion compared with that in control rats. Peak intensity (PI) values correlated significantly with serum KIM-1 levels and fibrosis scores in HN rats. An early decline in PI values was also observed in chronic kidney disease (CKD) stage 1 patients with HN compared with the controls (61.1±4.52 dB versus 65.80±7.10 dB) and correlated with renal function in the patients with HN. In contrast, an increase in time to reach PI values was detected in HN patients with stage 1 CKD (15.14±1.75 s versus 14.52±4.75 s) and was more pronounced in CKD stage 4 patients (67.32±3.29 s). CEUS was able to detect abnormal renal perfusion in early CKD with HN, which correlated with renal function decline, suggesting that CEUS could be used as a noninvasive tool for assessing renal function in patients with HN. |
| first_indexed | 2024-04-12T06:12:10Z |
| format | Article |
| id | doaj.art-db239dea127b4181b4103cafdad74cd9 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-04-12T06:12:10Z |
| publishDate | 2022-07-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-db239dea127b4181b4103cafdad74cd92022-12-22T03:44:40ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112022-07-0115710.1242/dmm.049382049382Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imagingLi He0Ze Li1Qunzi Zhang2Yini Chen3Yihui Gao4Teng Chen5Niansong Wang6Lixin Jiang7Ying Fan8 Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Ultrasonic Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Ultrasonic Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Ultrasonic Department, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Diagnostic tools for the early detection of renal injury caused by hyperuricemia are still lacking. Here, we investigated whether contrast-enhanced ultrasound (CEUS) could be used as a diagnostic tool for hyperuricemic nephropathy (HN). In the HN rat model, CEUS detected a significant decline in renal cortical perfusion compared with that in control rats. Peak intensity (PI) values correlated significantly with serum KIM-1 levels and fibrosis scores in HN rats. An early decline in PI values was also observed in chronic kidney disease (CKD) stage 1 patients with HN compared with the controls (61.1±4.52 dB versus 65.80±7.10 dB) and correlated with renal function in the patients with HN. In contrast, an increase in time to reach PI values was detected in HN patients with stage 1 CKD (15.14±1.75 s versus 14.52±4.75 s) and was more pronounced in CKD stage 4 patients (67.32±3.29 s). CEUS was able to detect abnormal renal perfusion in early CKD with HN, which correlated with renal function decline, suggesting that CEUS could be used as a noninvasive tool for assessing renal function in patients with HN.http://dmm.biologists.org/content/15/7/dmm049382hyperuricemic nephropathyhyperuricemiaceusrenal cortical perfusionpeak intensity |
| spellingShingle | Li He Ze Li Qunzi Zhang Yini Chen Yihui Gao Teng Chen Niansong Wang Lixin Jiang Ying Fan Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging Disease Models & Mechanisms hyperuricemic nephropathy hyperuricemia ceus renal cortical perfusion peak intensity |
| title | Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging |
| title_full | Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging |
| title_fullStr | Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging |
| title_full_unstemmed | Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging |
| title_short | Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging |
| title_sort | evaluation of renal microperfusion in hyperuricemic nephropathy by contrast enhanced ultrasound imaging |
| topic | hyperuricemic nephropathy hyperuricemia ceus renal cortical perfusion peak intensity |
| url | http://dmm.biologists.org/content/15/7/dmm049382 |
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