Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications
The wide range of secondary metabolites in medicinal plant extracts are used to treat and manage various diseases worldwide but more recently plant-mediated bio-nanotechnology is rapidly generating great research interest. Herein, the in-vitro study of the antidiabetic, anti-inflammatory, antiglycat...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nigerian Academy of Science
2023-06-01
|
| Series: | The Proceedings of the Nigerian Academy of Science |
| Subjects: | |
| Online Access: | https://nasjournal.org.ng/site/index.php/pnas/article/view/488/226 |
| _version_ | 1797783407928803328 |
|---|---|
| author | Olasunkanmi K. Awote Mutiu I. Kazeem Anthony B. Ojekale Oyinkansolami B. Ayanleye Hamdalat T. Ramoni |
| author_facet | Olasunkanmi K. Awote Mutiu I. Kazeem Anthony B. Ojekale Oyinkansolami B. Ayanleye Hamdalat T. Ramoni |
| author_sort | Olasunkanmi K. Awote |
| collection | DOAJ |
| description | The wide range of secondary metabolites in medicinal plant extracts are used to treat and manage various diseases worldwide but more recently plant-mediated bio-nanotechnology is rapidly generating great research interest. Herein, the in-vitro study of the antidiabetic, anti-inflammatory, antiglycation, and antioxidant potentials of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts was evaluated. The synthesized AgNPs was characterized by UV-visible spectrophotometer, Fourier transform infrared spectroscopy (FT-IR) and Scanning electron microscopy (SEM). The antioxidant activity was evaluated via reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH), total antioxidant capacity (TAC) and nitric oxide scavenging assays; antidiabetic activity was evaluated with α-glucosidase and α-amylase inhibitory assays; antiglycation activity was evaluated using fructosamine inhibitory assay, and anti-inflammatory activity was performed using trypsin inhibitory and albumin denaturation assays. The AgNPs from all the plant parts showed good biological potentials investigated compared to the plant extracts however, the synthesized AgNPs using the leaf aqueous extract (AgNPs-JsL) showed a better antioxidant, antidiabetic, antiglycation, and anti-inflammatory potentials with an essential quality absorption band in the ultraviolet region of 410 nm and average size distribution of 50.47nm. In conclusion, all the parts of J. secunda showed substantial antidiabetic, antioxidant, antiglycation and anti-inflammatory potentials with high yield of various bioactive metabolites, however, the AgNPs-JsL was more potent followed by the flower, stem and roots extracts, respectively. |
| first_indexed | 2024-03-13T00:25:36Z |
| format | Article |
| id | doaj.art-db23ef59282844a08e11adf98f1a1abf |
| institution | Directory Open Access Journal |
| issn | 0794-7976 2705-327X |
| language | English |
| last_indexed | 2024-03-13T00:25:36Z |
| publishDate | 2023-06-01 |
| publisher | Nigerian Academy of Science |
| record_format | Article |
| series | The Proceedings of the Nigerian Academy of Science |
| spelling | doaj.art-db23ef59282844a08e11adf98f1a1abf2023-07-11T07:20:38ZengNigerian Academy of ScienceThe Proceedings of the Nigerian Academy of Science0794-79762705-327X2023-06-0116187105https://doi.org/10.57046/WTNO8179Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complicationsOlasunkanmi K. Awote0Mutiu I. Kazeem1Anthony B. Ojekale2Oyinkansolami B. Ayanleye3Hamdalat T. Ramoni4Department of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos State, NigeriaDepartment of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos State, NigeriaDepartment of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos State, NigeriaDepartment of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos State, NigeriaDepartment of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos State, NigeriaThe wide range of secondary metabolites in medicinal plant extracts are used to treat and manage various diseases worldwide but more recently plant-mediated bio-nanotechnology is rapidly generating great research interest. Herein, the in-vitro study of the antidiabetic, anti-inflammatory, antiglycation, and antioxidant potentials of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts was evaluated. The synthesized AgNPs was characterized by UV-visible spectrophotometer, Fourier transform infrared spectroscopy (FT-IR) and Scanning electron microscopy (SEM). The antioxidant activity was evaluated via reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH), total antioxidant capacity (TAC) and nitric oxide scavenging assays; antidiabetic activity was evaluated with α-glucosidase and α-amylase inhibitory assays; antiglycation activity was evaluated using fructosamine inhibitory assay, and anti-inflammatory activity was performed using trypsin inhibitory and albumin denaturation assays. The AgNPs from all the plant parts showed good biological potentials investigated compared to the plant extracts however, the synthesized AgNPs using the leaf aqueous extract (AgNPs-JsL) showed a better antioxidant, antidiabetic, antiglycation, and anti-inflammatory potentials with an essential quality absorption band in the ultraviolet region of 410 nm and average size distribution of 50.47nm. In conclusion, all the parts of J. secunda showed substantial antidiabetic, antioxidant, antiglycation and anti-inflammatory potentials with high yield of various bioactive metabolites, however, the AgNPs-JsL was more potent followed by the flower, stem and roots extracts, respectively.https://nasjournal.org.ng/site/index.php/pnas/article/view/488/226justicia secundasilver nanoparticlesphytochemistrydiabetes and its complicationsantioxidantadvanced glycated end products (ages)hyperglycemia |
| spellingShingle | Olasunkanmi K. Awote Mutiu I. Kazeem Anthony B. Ojekale Oyinkansolami B. Ayanleye Hamdalat T. Ramoni Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications The Proceedings of the Nigerian Academy of Science justicia secunda silver nanoparticles phytochemistry diabetes and its complications antioxidant advanced glycated end products (ages) hyperglycemia |
| title | Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications |
| title_full | Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications |
| title_fullStr | Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications |
| title_full_unstemmed | Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications |
| title_short | Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications |
| title_sort | prospects of silver nanoparticles agnps synthesized by justicia secunda aqueous extracts on diabetes and its related complications |
| topic | justicia secunda silver nanoparticles phytochemistry diabetes and its complications antioxidant advanced glycated end products (ages) hyperglycemia |
| url | https://nasjournal.org.ng/site/index.php/pnas/article/view/488/226 |
| work_keys_str_mv | AT olasunkanmikawote prospectsofsilvernanoparticlesagnpssynthesizedbyjusticiasecundaaqueousextractsondiabetesanditsrelatedcomplications AT mutiuikazeem prospectsofsilvernanoparticlesagnpssynthesizedbyjusticiasecundaaqueousextractsondiabetesanditsrelatedcomplications AT anthonybojekale prospectsofsilvernanoparticlesagnpssynthesizedbyjusticiasecundaaqueousextractsondiabetesanditsrelatedcomplications AT oyinkansolamibayanleye prospectsofsilvernanoparticlesagnpssynthesizedbyjusticiasecundaaqueousextractsondiabetesanditsrelatedcomplications AT hamdalattramoni prospectsofsilvernanoparticlesagnpssynthesizedbyjusticiasecundaaqueousextractsondiabetesanditsrelatedcomplications |