Twelve-hour normothermic liver perfusion in a rat model: characterization of the changes in the ex-situ bio-molecular phenotype and metabolism

Abstract The partial understanding of the biological events that occur during normothermic machine perfusion (NMP) and particularly during prolonged perfusion might hinder its deployment in clinical transplantation. The aim of our study was to implement a rat model of prolonged NMP to characterize t...

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Bibliographic Details
Main Authors: Daniele Dondossola, Caterina Lonati, Michele Battistin, Luigi Vivona, Alberto Zanella, Marco Maggioni, Vaira Valentina, Laimdota Zizmare, Christoph Trautwein, Andrea Schlegel, Stefano Gatti
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56433-3