TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

The survival of patients with glioblastoma (GBM) is poor. The main cause is the presence of glioma stem cells (GSCs), exceptionally resistant to temozolomide (TMZ) treatment. This last may be related to the heterogeneous expression of ion channels, among them TRPML2. Its mRNA expression was evaluate...

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Bibliographic Details
Main Authors: Maria Beatrice Morelli, Massimo Nabissi, Consuelo Amantini, Federica Maggi, Lucia Ricci-Vitiani, Roberto Pallini, Giorgio Santoni
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
glioma stem cells
heterogeneity
ion channels
transient receptor potential mucolipin-2
temozolomide
Online Access:https://www.mdpi.com/1422-0067/23/23/15356

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