Targeting inflammation with collagen
Abstract Tissue damage caused by an infection or an autoimmune disease triggers degradation of collagen in the extracellular matrix (ECM), which further enhances inflammation. Therefore, improving ECM in an inflamed tissue can be exploited as a potential therapeutic target. A recent study emphasised...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctm2.831 |
| _version_ | 1811241798634307584 |
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| author | Dennis Schwarz Marie Lipoldová Holger Reinecke Yahya Sohrabi |
| author_facet | Dennis Schwarz Marie Lipoldová Holger Reinecke Yahya Sohrabi |
| author_sort | Dennis Schwarz |
| collection | DOAJ |
| description | Abstract Tissue damage caused by an infection or an autoimmune disease triggers degradation of collagen in the extracellular matrix (ECM), which further enhances inflammation. Therefore, improving ECM in an inflamed tissue can be exploited as a potential therapeutic target. A recent study emphasised an innovative approach against COVID‐19 using polymerised type I collagen (PTIC) that improves disease severity through a hitherto unknown mechanism. In this paper, we provide an overview of potential mechanism that may explain the anti‐inflammatory effect of collagen peptides. In addition,the paper includes a brief summary of possible side effect of collagen deposition in inflammatory diseases. Altogether, current knowledge suggests that collagen may potentially reduce the residual risk in inflammatory diseases; however, the detailed mechanism remains elusive. |
| first_indexed | 2024-04-12T13:41:40Z |
| format | Article |
| id | doaj.art-db27250b4e5e4536b48eba8cf23408ed |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-04-12T13:41:40Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-db27250b4e5e4536b48eba8cf23408ed2022-12-22T03:30:50ZengWileyClinical and Translational Medicine2001-13262022-05-01125n/an/a10.1002/ctm2.831Targeting inflammation with collagenDennis Schwarz0Marie Lipoldová1Holger Reinecke2Yahya Sohrabi3Department of Cardiology I ‐ Coronary and Peripheral Vascular Disease, Heart Failure University Hospital Münster Münster GermanyLaboratory of Signal Transduction Institutes of Molecular Genetics of the Czech Academy of Sciences Prague CzechiaDepartment of Cardiology I ‐ Coronary and Peripheral Vascular Disease, Heart Failure University Hospital Münster Münster GermanyDepartment of Cardiology I ‐ Coronary and Peripheral Vascular Disease, Heart Failure University Hospital Münster Münster GermanyAbstract Tissue damage caused by an infection or an autoimmune disease triggers degradation of collagen in the extracellular matrix (ECM), which further enhances inflammation. Therefore, improving ECM in an inflamed tissue can be exploited as a potential therapeutic target. A recent study emphasised an innovative approach against COVID‐19 using polymerised type I collagen (PTIC) that improves disease severity through a hitherto unknown mechanism. In this paper, we provide an overview of potential mechanism that may explain the anti‐inflammatory effect of collagen peptides. In addition,the paper includes a brief summary of possible side effect of collagen deposition in inflammatory diseases. Altogether, current knowledge suggests that collagen may potentially reduce the residual risk in inflammatory diseases; however, the detailed mechanism remains elusive.https://doi.org/10.1002/ctm2.831collagenCOVID‐19ECMinflammationMMPs |
| spellingShingle | Dennis Schwarz Marie Lipoldová Holger Reinecke Yahya Sohrabi Targeting inflammation with collagen Clinical and Translational Medicine collagen COVID‐19 ECM inflammation MMPs |
| title | Targeting inflammation with collagen |
| title_full | Targeting inflammation with collagen |
| title_fullStr | Targeting inflammation with collagen |
| title_full_unstemmed | Targeting inflammation with collagen |
| title_short | Targeting inflammation with collagen |
| title_sort | targeting inflammation with collagen |
| topic | collagen COVID‐19 ECM inflammation MMPs |
| url | https://doi.org/10.1002/ctm2.831 |
| work_keys_str_mv | AT dennisschwarz targetinginflammationwithcollagen AT marielipoldova targetinginflammationwithcollagen AT holgerreinecke targetinginflammationwithcollagen AT yahyasohrabi targetinginflammationwithcollagen |