Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy
Introduction Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow‐up periods are growing longer, the rate of unusual visceral metastases may increase. Case presentation A 68‐year‐old man diagnosed with lung, pancreatic, and renal metastases 9 y...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-05-01
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| Series: | IJU Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iju5.12261 |
| _version_ | 1819320004635525120 |
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| author | Shotaro Yasuoka Takeshi Yuasa Motohiro Fujiwara Junko Fujisaki Kentaro Inamura Yoshinobu Komai Noboru Numao Shinya Yamamoto Junji Yonese |
| author_facet | Shotaro Yasuoka Takeshi Yuasa Motohiro Fujiwara Junko Fujisaki Kentaro Inamura Yoshinobu Komai Noboru Numao Shinya Yamamoto Junji Yonese |
| author_sort | Shotaro Yasuoka |
| collection | DOAJ |
| description | Introduction Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow‐up periods are growing longer, the rate of unusual visceral metastases may increase. Case presentation A 68‐year‐old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow‐up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow‐up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma. Conclusion We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long‐term follow‐up. |
| first_indexed | 2024-12-24T11:12:41Z |
| format | Article |
| id | doaj.art-db2770bc79444e749f76a3889bc07507 |
| institution | Directory Open Access Journal |
| issn | 2577-171X |
| language | English |
| last_indexed | 2024-12-24T11:12:41Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | IJU Case Reports |
| spelling | doaj.art-db2770bc79444e749f76a3889bc075072022-12-21T16:58:28ZengWileyIJU Case Reports2577-171X2021-05-014313613810.1002/iju5.12261Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapyShotaro Yasuoka0Takeshi Yuasa1Motohiro Fujiwara2Junko Fujisaki3Kentaro Inamura4Yoshinobu Komai5Noboru Numao6Shinya Yamamoto7Junji Yonese8Departments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartment of Gastroenterological Medicine Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartment of Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo JapanDepartments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanDepartments of Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research TokyoJapanIntroduction Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow‐up periods are growing longer, the rate of unusual visceral metastases may increase. Case presentation A 68‐year‐old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow‐up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow‐up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma. Conclusion We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long‐term follow‐up.https://doi.org/10.1002/iju5.12261bladder metastasisesophageal metastasisrenal cell cancer |
| spellingShingle | Shotaro Yasuoka Takeshi Yuasa Motohiro Fujiwara Junko Fujisaki Kentaro Inamura Yoshinobu Komai Noboru Numao Shinya Yamamoto Junji Yonese Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy IJU Case Reports bladder metastasis esophageal metastasis renal cell cancer |
| title | Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy |
| title_full | Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy |
| title_fullStr | Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy |
| title_full_unstemmed | Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy |
| title_short | Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy |
| title_sort | unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy |
| topic | bladder metastasis esophageal metastasis renal cell cancer |
| url | https://doi.org/10.1002/iju5.12261 |
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