Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals
Background: Many studies identified the risk factors and prognostic factors related to in-hospital COVID-19 mortality using sophisticated laboratory tests. Cost and the availability of supporting blood tests may be problematic in resource-limited settings. This multicenter cohort study was conducted...
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| Format: | Article |
| Language: | English |
| Published: |
Interna Publishing
2022-01-01
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| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | http://actamedindones.org/index.php/ijim/article/view/1921 |
| _version_ | 1798026133341470720 |
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| author | Siti Rizny F. Saldi Eka Dian Safitri Siti Setiati Respati W Ranakusuma Jessica Marsigit Muhammad K Azwar Puji Astuti Cut Yulia Indah Sari Rahmi Istanti Mira Yulianti Cleopas Martin Rumende Evy Yunihastuti Adityo Susilo Kuntjoro Harimurti Lies Dina Liastuti Trimartani Trimartani Ratna Dwi Restuti Ari Fahrial Syam |
| author_facet | Siti Rizny F. Saldi Eka Dian Safitri Siti Setiati Respati W Ranakusuma Jessica Marsigit Muhammad K Azwar Puji Astuti Cut Yulia Indah Sari Rahmi Istanti Mira Yulianti Cleopas Martin Rumende Evy Yunihastuti Adityo Susilo Kuntjoro Harimurti Lies Dina Liastuti Trimartani Trimartani Ratna Dwi Restuti Ari Fahrial Syam |
| author_sort | Siti Rizny F. Saldi |
| collection | DOAJ |
| description | Background: Many studies identified the risk factors and prognostic factors related to in-hospital COVID-19 mortality using sophisticated laboratory tests. Cost and the availability of supporting blood tests may be problematic in resource-limited settings. This multicenter cohort study was conducted to assess the factors associated with mortality of COVID-19 patients aged 18 years and older, based on history taking, physical examination, and simple blood tests to be used in resource-limited settings. Methods: The study was conducted between July 2020 and January 2021 in five COVID-19 referral hospitals in Indonesia. Among 1048 confirmed cases of COVID-19, 160 (15%) died during hospitalization. Results: Multivariate analysis showed eight predictors of in-hospital mortality, namely increased age, chronic kidney disease, chronic obstructive pulmonary disease, fatigue, dyspnea, altered mental status, neutrophil-lymphocyte ratio (NLR) ≥ 5.8, and severe-critical condition. This scoring system had an Area-under-the-curve (AUC) of 84.7%. With cut-off score of 6, the sensitivity was 76.3% and the specificity was 78.2%. Conclusion: The result of this practical prognostic scoring system may be a guide to decision making of physicians and help in the education of family members related to the possible outcome. |
| first_indexed | 2024-04-11T18:30:13Z |
| format | Article |
| id | doaj.art-db27d23979b449b2ba286ff534879f74 |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-04-11T18:30:13Z |
| publishDate | 2022-01-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-db27d23979b449b2ba286ff534879f742022-12-22T04:09:29ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-01-01534466Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral HospitalsSiti Rizny F. Saldi0Eka Dian Safitri1Siti Setiati2Respati W Ranakusuma3Jessica Marsigit4Muhammad K Azwar5Puji Astuti6Cut Yulia Indah Sari7Rahmi Istanti8Mira Yulianti9Cleopas Martin Rumende10Evy Yunihastuti11Adityo Susilo12Kuntjoro Harimurti13Lies Dina Liastuti14Trimartani Trimartani15Ratna Dwi Restuti16Ari Fahrial Syam17Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, IndonesiaClinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia1. Division of Geriatrics, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia –Cipto Mangunkusumo Hospital, Jakarta, Indonesia 2. Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, IndonesiaClinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaClinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaClinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaPulmonologist, Cengkareng District Hospital, Jakarta, IndonesiaPulmonologist, Jakarta Islamic Hospital, Cempaka Putih, Jakarta, IndonesiaClinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Pulmonology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Pulmonology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Tropical Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia1. Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. 2. Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, IndonesiaCipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Ear, Nose, and Throat, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Ear, Nose, and Throat, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaBackground: Many studies identified the risk factors and prognostic factors related to in-hospital COVID-19 mortality using sophisticated laboratory tests. Cost and the availability of supporting blood tests may be problematic in resource-limited settings. This multicenter cohort study was conducted to assess the factors associated with mortality of COVID-19 patients aged 18 years and older, based on history taking, physical examination, and simple blood tests to be used in resource-limited settings. Methods: The study was conducted between July 2020 and January 2021 in five COVID-19 referral hospitals in Indonesia. Among 1048 confirmed cases of COVID-19, 160 (15%) died during hospitalization. Results: Multivariate analysis showed eight predictors of in-hospital mortality, namely increased age, chronic kidney disease, chronic obstructive pulmonary disease, fatigue, dyspnea, altered mental status, neutrophil-lymphocyte ratio (NLR) ≥ 5.8, and severe-critical condition. This scoring system had an Area-under-the-curve (AUC) of 84.7%. With cut-off score of 6, the sensitivity was 76.3% and the specificity was 78.2%. Conclusion: The result of this practical prognostic scoring system may be a guide to decision making of physicians and help in the education of family members related to the possible outcome.http://actamedindones.org/index.php/ijim/article/view/1921covid-19prognosticpredictive scoremortalityresource-limited settings |
| spellingShingle | Siti Rizny F. Saldi Eka Dian Safitri Siti Setiati Respati W Ranakusuma Jessica Marsigit Muhammad K Azwar Puji Astuti Cut Yulia Indah Sari Rahmi Istanti Mira Yulianti Cleopas Martin Rumende Evy Yunihastuti Adityo Susilo Kuntjoro Harimurti Lies Dina Liastuti Trimartani Trimartani Ratna Dwi Restuti Ari Fahrial Syam Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals Acta Medica Indonesiana covid-19 prognostic predictive score mortality resource-limited settings |
| title | Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals |
| title_full | Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals |
| title_fullStr | Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals |
| title_full_unstemmed | Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals |
| title_short | Prognostic Scoring System for Mortality of Hospitalized COVID-19 Patients in Resource-Limited Settings: A Multicenter Study from COVID-19 Referral Hospitals |
| title_sort | prognostic scoring system for mortality of hospitalized covid 19 patients in resource limited settings a multicenter study from covid 19 referral hospitals |
| topic | covid-19 prognostic predictive score mortality resource-limited settings |
| url | http://actamedindones.org/index.php/ijim/article/view/1921 |
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