Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy
Human cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral replication. HCMV gene products have been described to directly interact and alter functional or structural aspects of host mitochondria. Current antivirals against HCMV, such as ganciclovir and letermovir, are design...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/5/1083 |
| _version_ | 1797598120582840320 |
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| author | Lauryn O. Bachman Kevin J. Zwezdaryk |
| author_facet | Lauryn O. Bachman Kevin J. Zwezdaryk |
| author_sort | Lauryn O. Bachman |
| collection | DOAJ |
| description | Human cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral replication. HCMV gene products have been described to directly interact and alter functional or structural aspects of host mitochondria. Current antivirals against HCMV, such as ganciclovir and letermovir, are designed against viral targets. Concerns with the current antivirals include toxicity and viral resistance. Targeting host mitochondrial function is a promising alternative or complimentary antiviral approach as (1) drugs targeting host mitochondrial function interact with host targets, minimizing viral resistance, and (2) host mitochondrial metabolism plays key roles in HCMV replication. This review describes how HCMV alters mitochondrial function and highlights pharmacological targets that can be exploited for novel antiviral development. |
| first_indexed | 2024-03-11T03:14:51Z |
| format | Article |
| id | doaj.art-db2b0e688a8d4a008303e7292b7f4e43 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T03:14:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-db2b0e688a8d4a008303e7292b7f4e432023-11-18T03:38:44ZengMDPI AGViruses1999-49152023-04-01155108310.3390/v15051083Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral StrategyLauryn O. Bachman0Kevin J. Zwezdaryk1Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA 70112, USADepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USAHuman cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral replication. HCMV gene products have been described to directly interact and alter functional or structural aspects of host mitochondria. Current antivirals against HCMV, such as ganciclovir and letermovir, are designed against viral targets. Concerns with the current antivirals include toxicity and viral resistance. Targeting host mitochondrial function is a promising alternative or complimentary antiviral approach as (1) drugs targeting host mitochondrial function interact with host targets, minimizing viral resistance, and (2) host mitochondrial metabolism plays key roles in HCMV replication. This review describes how HCMV alters mitochondrial function and highlights pharmacological targets that can be exploited for novel antiviral development.https://www.mdpi.com/1999-4915/15/5/1083cytomegalovirusCMVmitochondriaETCmetabolismantivirals |
| spellingShingle | Lauryn O. Bachman Kevin J. Zwezdaryk Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy Viruses cytomegalovirus CMV mitochondria ETC metabolism antivirals |
| title | Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy |
| title_full | Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy |
| title_fullStr | Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy |
| title_full_unstemmed | Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy |
| title_short | Targeting the Host Mitochondria as a Novel Human Cytomegalovirus Antiviral Strategy |
| title_sort | targeting the host mitochondria as a novel human cytomegalovirus antiviral strategy |
| topic | cytomegalovirus CMV mitochondria ETC metabolism antivirals |
| url | https://www.mdpi.com/1999-4915/15/5/1083 |
| work_keys_str_mv | AT laurynobachman targetingthehostmitochondriaasanovelhumancytomegalovirusantiviralstrategy AT kevinjzwezdaryk targetingthehostmitochondriaasanovelhumancytomegalovirusantiviralstrategy |