Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke
Background Ischemic stroke is a leading cause of morbidity and mortality worldwide. One possible predictor is the use of biomarkers especially neurofilament light chain (NFL). Objectives To explore whether NFL could predict clinical outcome and hemorrhagic transformation in moderate to severe stroke...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-12-01
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| Series: | Journal of Central Nervous System Disease |
| Online Access: | https://doi.org/10.1177/11795735221147212 |
| _version_ | 1797960567122558976 |
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| author | Wanakorn Rattanawong MD Tatchaporn Ongphichetmetha MD Thiravat Hemachudha MD Poosanu Thanapornsangsuth MD |
| author_facet | Wanakorn Rattanawong MD Tatchaporn Ongphichetmetha MD Thiravat Hemachudha MD Poosanu Thanapornsangsuth MD |
| author_sort | Wanakorn Rattanawong MD |
| collection | DOAJ |
| description | Background Ischemic stroke is a leading cause of morbidity and mortality worldwide. One possible predictor is the use of biomarkers especially neurofilament light chain (NFL). Objectives To explore whether NFL could predict clinical outcome and hemorrhagic transformation in moderate to severe stroke. Design Single center prospective cohort study. Methods Fifty-one moderate to severe ischemic stroke patients were recruited. Blood NFL was obtained from patients at admission (First sample) and 24-96 hours later (Second sample). NFL was analyzed with the ultrasensitive single molecule array (Simoa). Later, we calculated incremental rate NFL (IRN) by changes in NFL per day from baseline. We evaluated National Institute of Health stroke scale (NIHSS), modified Rankins score (mRs), and the presence of hemorrhagic transformation (HT). Results IRN was found to be higher in patients with unfavorable outcome (7.12 vs 24.07, P = .04) as well as Second sample (49.06 vs 71.41, P = .011), while NFL First sample was not significant. IRN had a great correlation with mRS (r = .552, P < .001). Univariate logistic regression model showed OR of IRN and Second sample to be 1.081 (95% CI 1.016-1.149, P = .013) and 1.019 (1.002-1.037, P = .03), respectively. Multiple logistic regression model has shown to be significant. In receiver operating analysis, IRN, Second sample, combined IRN with NIHSS and combined Second sample with NIHSS showed AUC (.744, P = .004; 0.713, P = .01; 0.805, P < .001; 0.803, P < .001, respectively). For HT, First sample and Second sample had significant difference with HT (Z = 2.13, P = .033; Z = 2.487, P = .013, respectively). Conclusion NFL was found to correlate and predict clinical outcome. In addition, it was found to correlate with HT. |
| first_indexed | 2024-04-11T00:47:17Z |
| format | Article |
| id | doaj.art-db2ba2b579804a289c4fe9ff84761807 |
| institution | Directory Open Access Journal |
| issn | 1179-5735 |
| language | English |
| last_indexed | 2024-04-11T00:47:17Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Central Nervous System Disease |
| spelling | doaj.art-db2ba2b579804a289c4fe9ff847618072023-01-05T14:03:18ZengSAGE PublishingJournal of Central Nervous System Disease1179-57352023-12-011510.1177/11795735221147212Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic strokeWanakorn Rattanawong MDTatchaporn Ongphichetmetha MDThiravat Hemachudha MDPoosanu Thanapornsangsuth MDBackground Ischemic stroke is a leading cause of morbidity and mortality worldwide. One possible predictor is the use of biomarkers especially neurofilament light chain (NFL). Objectives To explore whether NFL could predict clinical outcome and hemorrhagic transformation in moderate to severe stroke. Design Single center prospective cohort study. Methods Fifty-one moderate to severe ischemic stroke patients were recruited. Blood NFL was obtained from patients at admission (First sample) and 24-96 hours later (Second sample). NFL was analyzed with the ultrasensitive single molecule array (Simoa). Later, we calculated incremental rate NFL (IRN) by changes in NFL per day from baseline. We evaluated National Institute of Health stroke scale (NIHSS), modified Rankins score (mRs), and the presence of hemorrhagic transformation (HT). Results IRN was found to be higher in patients with unfavorable outcome (7.12 vs 24.07, P = .04) as well as Second sample (49.06 vs 71.41, P = .011), while NFL First sample was not significant. IRN had a great correlation with mRS (r = .552, P < .001). Univariate logistic regression model showed OR of IRN and Second sample to be 1.081 (95% CI 1.016-1.149, P = .013) and 1.019 (1.002-1.037, P = .03), respectively. Multiple logistic regression model has shown to be significant. In receiver operating analysis, IRN, Second sample, combined IRN with NIHSS and combined Second sample with NIHSS showed AUC (.744, P = .004; 0.713, P = .01; 0.805, P < .001; 0.803, P < .001, respectively). For HT, First sample and Second sample had significant difference with HT (Z = 2.13, P = .033; Z = 2.487, P = .013, respectively). Conclusion NFL was found to correlate and predict clinical outcome. In addition, it was found to correlate with HT.https://doi.org/10.1177/11795735221147212 |
| spellingShingle | Wanakorn Rattanawong MD Tatchaporn Ongphichetmetha MD Thiravat Hemachudha MD Poosanu Thanapornsangsuth MD Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke Journal of Central Nervous System Disease |
| title | Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke |
| title_full | Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke |
| title_fullStr | Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke |
| title_full_unstemmed | Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke |
| title_short | Neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke |
| title_sort | neurofilament light is associated with clinical outcome and hemorrhagic transformation in moderate to severe ischemic stroke |
| url | https://doi.org/10.1177/11795735221147212 |
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