Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children
Background: In 2010, Greenland introduced the 13-valent pneumococcal conjugate vaccine (Prevnar 13®– PCV-13) in the childhood immunisation program. The authors aimed to evaluate the impact of PCV-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | International Journal of Circumpolar Health |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/22423982.2017.1309504 |
| _version_ | 1819070429861511168 |
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| author | Johan Emdal Navne Anders Koch Hans-Christian Slotved Mikael Andersson Mads Melbye Karin Ladefoged Malene Børresen |
| author_facet | Johan Emdal Navne Anders Koch Hans-Christian Slotved Mikael Andersson Mads Melbye Karin Ladefoged Malene Børresen |
| author_sort | Johan Emdal Navne |
| collection | DOAJ |
| description | Background: In 2010, Greenland introduced the 13-valent pneumococcal conjugate vaccine (Prevnar 13®– PCV-13) in the childhood immunisation program. The authors aimed to evaluate the impact of PCV-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children. Method: In 2013 a cross-sectional population-based study of nasopharyngeal carriage was conducted among Greenlandic children aged 0–6 years and results were compared with an equivalent study from 2011. Nasopharyngeal swab samples were tested for Streptococcus pneumoniae, non-typeable Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. Pneumococcal serotyping was performed by Quellung reaction and serotype-specific antisera. Statistical analysis included logistic regression models, adjusting for known risk factors. Result: A total of 377 nasopharyngeal samples were collected. Overall carriage rate of S. pneumoniae remained unchanged from 2011 to 2013 (51% and 56%, p=0.13), but significant serotype shifts were observed among both vaccinated and unvaccinated children with marked reductions in carriage of vaccine-type pneumococci, counterbalanced by increasing carriage of non-vaccine types. Carriage rate of S. aureus decreased significantly among vaccinated children whereas that of M. catarrhalis increased. Conclusion: PCV-13 introduction in Greenland is associated with significant changes in nasopharyngeal bacterial carriage. Continued surveillance is warranted to clarify whether these changes are persistent, and affect the pattern of respiratory and invasive diseases in Greenland. |
| first_indexed | 2024-12-21T17:05:48Z |
| format | Article |
| id | doaj.art-db2da38f27544e8b96f4798845624f6e |
| institution | Directory Open Access Journal |
| issn | 2242-3982 |
| language | English |
| last_indexed | 2024-12-21T17:05:48Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Circumpolar Health |
| spelling | doaj.art-db2da38f27544e8b96f4798845624f6e2022-12-21T18:56:32ZengTaylor & Francis GroupInternational Journal of Circumpolar Health2242-39822017-01-0176110.1080/22423982.2017.13095041309504Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic childrenJohan Emdal Navne0Anders Koch1Hans-Christian Slotved2Mikael Andersson3Mads Melbye4Karin Ladefoged5Malene Børresen6Statens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutStatens Serum InstitutQueen Ingrids HospitalStatens Serum InstitutBackground: In 2010, Greenland introduced the 13-valent pneumococcal conjugate vaccine (Prevnar 13®– PCV-13) in the childhood immunisation program. The authors aimed to evaluate the impact of PCV-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children. Method: In 2013 a cross-sectional population-based study of nasopharyngeal carriage was conducted among Greenlandic children aged 0–6 years and results were compared with an equivalent study from 2011. Nasopharyngeal swab samples were tested for Streptococcus pneumoniae, non-typeable Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. Pneumococcal serotyping was performed by Quellung reaction and serotype-specific antisera. Statistical analysis included logistic regression models, adjusting for known risk factors. Result: A total of 377 nasopharyngeal samples were collected. Overall carriage rate of S. pneumoniae remained unchanged from 2011 to 2013 (51% and 56%, p=0.13), but significant serotype shifts were observed among both vaccinated and unvaccinated children with marked reductions in carriage of vaccine-type pneumococci, counterbalanced by increasing carriage of non-vaccine types. Carriage rate of S. aureus decreased significantly among vaccinated children whereas that of M. catarrhalis increased. Conclusion: PCV-13 introduction in Greenland is associated with significant changes in nasopharyngeal bacterial carriage. Continued surveillance is warranted to clarify whether these changes are persistent, and affect the pattern of respiratory and invasive diseases in Greenland.http://dx.doi.org/10.1080/22423982.2017.1309504PCV-13carriageInuitrespiratory infectionspneumococcus |
| spellingShingle | Johan Emdal Navne Anders Koch Hans-Christian Slotved Mikael Andersson Mads Melbye Karin Ladefoged Malene Børresen Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children International Journal of Circumpolar Health PCV-13 carriage Inuit respiratory infections pneumococcus |
| title | Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children |
| title_full | Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children |
| title_fullStr | Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children |
| title_full_unstemmed | Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children |
| title_short | Effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among Greenlandic children |
| title_sort | effect of the 13 valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among greenlandic children |
| topic | PCV-13 carriage Inuit respiratory infections pneumococcus |
| url | http://dx.doi.org/10.1080/22423982.2017.1309504 |
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