Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine
Nanotechnology changed our understanding of physics and chemics and influenced the biomedical field. Iron oxide nanoparticles (IONs) are one of the first emerging biomedical applications of nanotechnology. The IONs are composed of iron oxide core exhibiting magnetism and coated with biocompatible mo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=1;spage=11;epage=17;aulast=Lu |
| _version_ | 1797902842374127616 |
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| author | Chia-Hung Lu Jong-Kai Hsiao |
| author_facet | Chia-Hung Lu Jong-Kai Hsiao |
| author_sort | Chia-Hung Lu |
| collection | DOAJ |
| description | Nanotechnology changed our understanding of physics and chemics and influenced the biomedical field. Iron oxide nanoparticles (IONs) are one of the first emerging biomedical applications of nanotechnology. The IONs are composed of iron oxide core exhibiting magnetism and coated with biocompatible molecules. The small size, strong magnetism, and biocompatibility of IONs facilitate the application of IONs in the medical imaging field. We listed several clinical available IONs including Resovist (Bayer Schering Pharma, Berlin, Germany) and Feridex intravenous (I.V.)/Endorem as magnetic resonance (MR) contrast agents for liver tumor detection. We also illustrated GastroMARK as a gastrointestinal contrast agent for MR imaging. Recently, IONs named Feraheme for treating iron-deficiency anemia have been approved by the Food and Drug Administration. Moreover, tumor ablation by IONs named NanoTherm has also been discussed. In addition to the clinical application, several potential biomedical applications of IONs including cancer-targeting capability by conjugating IONs with cancer-specific ligands, cell trafficking tools, or tumor ablation agents have also been discussed. With the growing awareness of nanotechnology, further application of IONs is still on the horizon that would shed light on biomedicine. |
| first_indexed | 2024-04-10T09:23:44Z |
| format | Article |
| id | doaj.art-db2dcea5697144a9b5bd5c641e1cd28c |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-04-10T09:23:44Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-db2dcea5697144a9b5bd5c641e1cd28c2023-02-20T07:29:11ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562023-01-01351111710.4103/tcmj.tcmj_65_22Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicineChia-Hung LuJong-Kai HsiaoNanotechnology changed our understanding of physics and chemics and influenced the biomedical field. Iron oxide nanoparticles (IONs) are one of the first emerging biomedical applications of nanotechnology. The IONs are composed of iron oxide core exhibiting magnetism and coated with biocompatible molecules. The small size, strong magnetism, and biocompatibility of IONs facilitate the application of IONs in the medical imaging field. We listed several clinical available IONs including Resovist (Bayer Schering Pharma, Berlin, Germany) and Feridex intravenous (I.V.)/Endorem as magnetic resonance (MR) contrast agents for liver tumor detection. We also illustrated GastroMARK as a gastrointestinal contrast agent for MR imaging. Recently, IONs named Feraheme for treating iron-deficiency anemia have been approved by the Food and Drug Administration. Moreover, tumor ablation by IONs named NanoTherm has also been discussed. In addition to the clinical application, several potential biomedical applications of IONs including cancer-targeting capability by conjugating IONs with cancer-specific ligands, cell trafficking tools, or tumor ablation agents have also been discussed. With the growing awareness of nanotechnology, further application of IONs is still on the horizon that would shed light on biomedicine.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=1;spage=11;epage=17;aulast=Luiron oxidemagnetic resonance imagingmolecular imagingnanotechnology |
| spellingShingle | Chia-Hung Lu Jong-Kai Hsiao Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine Tzu-Chi Medical Journal iron oxide magnetic resonance imaging molecular imaging nanotechnology |
| title | Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine |
| title_full | Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine |
| title_fullStr | Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine |
| title_full_unstemmed | Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine |
| title_short | Diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine |
| title_sort | diagnostic and therapeutic roles of iron oxide nanoparticles in biomedicine |
| topic | iron oxide magnetic resonance imaging molecular imaging nanotechnology |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2023;volume=35;issue=1;spage=11;epage=17;aulast=Lu |
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