4’-O-Methylbroussochalcone B as a novel tubulin polymerization inhibitor suppressed the proliferation and migration of acute myeloid leukaemia cells

4’-O-Methylbroussochalcone B as a novel tubulin polymerization inhibitor suppressed the proliferation and migration of acute myeloid leukaemia cells

Abstract Background Recent years, survival rates of human with high-risk acute myeloid leukaemia (AML) have not raised substantially. This research aimed to investigate the role of 4′-O-Methylbroussochalcone B, for the treatment of human AML. Methods Firstly, we evaluated the effects of six chalcone...

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Bibliographic Details
Main Authors: Ziying Liu, Changshui Wang, Yali Wang, Lei Wang, Yueyuan Zhang, Genquan Yan
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Cancer
Subjects:
4′-O-Methylbroussochalcone B
Acute myeloid leukaemia
Migration
Colchicine
Tubulin polymerization inhibitor
Online Access:https://doi.org/10.1186/s12885-020-07759-4

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