Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway
Erythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is mostly restricted to stem cell niches in adults but is reactivated in pathological conditions including lesions in...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/7/140 |
| _version_ | 1797563835494694912 |
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| author | Sarah Baudet Johann Bécret Xavier Nicol |
| author_facet | Sarah Baudet Johann Bécret Xavier Nicol |
| author_sort | Sarah Baudet |
| collection | DOAJ |
| description | Erythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is mostly restricted to stem cell niches in adults but is reactivated in pathological conditions including lesions in the heart, lung, or nervous system. They are also often misregulated in tumors. A wide range of molecular tools enabling the manipulation of the ephrin-A:EphA system are available, ranging from small molecules to peptides and genetically-encoded strategies. Their mechanism is either direct, targeting EphA receptors, or indirect through the modification of intracellular downstream pathways. Approaches enabling manipulation of ephrin-A:EphA forward signaling for the dissection of its signaling cascade, the investigation of its physiological roles or the development of therapeutic strategies are summarized here. |
| first_indexed | 2024-03-10T18:48:49Z |
| format | Article |
| id | doaj.art-db2e39f12b7d4db79248c26e6e578714 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T18:48:49Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-db2e39f12b7d4db79248c26e6e5787142023-11-20T05:22:04ZengMDPI AGPharmaceuticals1424-82472020-06-0113714010.3390/ph13070140Approaches to Manipulate Ephrin-A:EphA Forward Signaling PathwaySarah Baudet0Johann Bécret1Xavier Nicol2Institut de la Vision, Sorbonne Université, Inserm, CNRS, 17 rue Moreau, F-75012 Paris, FranceInstitut de la Vision, Sorbonne Université, Inserm, CNRS, 17 rue Moreau, F-75012 Paris, FranceInstitut de la Vision, Sorbonne Université, Inserm, CNRS, 17 rue Moreau, F-75012 Paris, FranceErythropoietin-producing hepatocellular carcinoma A (EphA) receptors and their ephrin-A ligands are key players of developmental events shaping the mature organism. Their expression is mostly restricted to stem cell niches in adults but is reactivated in pathological conditions including lesions in the heart, lung, or nervous system. They are also often misregulated in tumors. A wide range of molecular tools enabling the manipulation of the ephrin-A:EphA system are available, ranging from small molecules to peptides and genetically-encoded strategies. Their mechanism is either direct, targeting EphA receptors, or indirect through the modification of intracellular downstream pathways. Approaches enabling manipulation of ephrin-A:EphA forward signaling for the dissection of its signaling cascade, the investigation of its physiological roles or the development of therapeutic strategies are summarized here.https://www.mdpi.com/1424-8247/13/7/140ephrinEphsecond messengerspeptidesvav guanine nucleotide exchange factorEphexin |
| spellingShingle | Sarah Baudet Johann Bécret Xavier Nicol Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway Pharmaceuticals ephrin Eph second messengers peptides vav guanine nucleotide exchange factor Ephexin |
| title | Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway |
| title_full | Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway |
| title_fullStr | Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway |
| title_full_unstemmed | Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway |
| title_short | Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway |
| title_sort | approaches to manipulate ephrin a epha forward signaling pathway |
| topic | ephrin Eph second messengers peptides vav guanine nucleotide exchange factor Ephexin |
| url | https://www.mdpi.com/1424-8247/13/7/140 |
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