Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway

Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway

Spinal cord injury-induced motor dysfunction is associated with neuroinflammation. Studies have shown that the triterpenoid lupenone, a natural product found in various plants, has a remarkable anti-inflammatory effect in the context of chronic inflammation. However, the effects of lupenone on acute...

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Bibliographic Details
Main Authors: Fudong Li, Xiaofei Sun, Kaiqiang Sun, Fanqi Kong, Xin Jiang, Qingjie Kong
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
inflammasome; inflammation; lupenone; microglia; polarization; pyroptosis; spinal cord injury
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1802;epage=1811;aulast=

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