Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System
Chronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and structure of the kidney, which is characterized by its irreversibility and slow and progressive evolution. Alzheimer’s disease (AD) is characterized by the extracellular accumulation of misfolded β...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/4/1459 |
| _version_ | 1797620227095134208 |
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| author | Ke Ma Zi-Run Zheng Yu Meng |
| author_facet | Ke Ma Zi-Run Zheng Yu Meng |
| author_sort | Ke Ma |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and structure of the kidney, which is characterized by its irreversibility and slow and progressive evolution. Alzheimer’s disease (AD) is characterized by the extracellular accumulation of misfolded β-amyloid (Aβ) proteins into senile plaques and the formation of neurofibrillary tangles (NFTs) containing hyperphosphorylated tau. In the aging population, CKD and AD are growing problems. CKD patients are prone to cognitive decline and AD. However, the connection between CKD and AD is still unclear. In this review, we take the lead in showing that the development of the pathophysiology of CKD may also cause or exacerbate AD, especially the renin-angiotensin system (RAS). In vivo studies had already shown that the increased expression of angiotensin-converting enzyme (ACE) produces a positive effect in aggravating AD, but ACE inhibitors (ACEIs) have protective effects against AD. Among the possible association of risk factors in CKD and AD, we mainly discuss the RAS in the systemic circulation and the brain. |
| first_indexed | 2024-03-11T08:38:07Z |
| format | Article |
| id | doaj.art-db2f6228d60d4e0e90787cd3af55aaef |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T08:38:07Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-db2f6228d60d4e0e90787cd3af55aaef2023-11-16T21:19:51ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01124145910.3390/jcm12041459Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin SystemKe Ma0Zi-Run Zheng1Yu Meng2The First Affiliated Hospital of Jinan University, Guangzhou 510000, ChinaThe First Affiliated Hospital of Jinan University, Guangzhou 510000, ChinaThe First Affiliated Hospital of Jinan University, Guangzhou 510000, ChinaChronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and structure of the kidney, which is characterized by its irreversibility and slow and progressive evolution. Alzheimer’s disease (AD) is characterized by the extracellular accumulation of misfolded β-amyloid (Aβ) proteins into senile plaques and the formation of neurofibrillary tangles (NFTs) containing hyperphosphorylated tau. In the aging population, CKD and AD are growing problems. CKD patients are prone to cognitive decline and AD. However, the connection between CKD and AD is still unclear. In this review, we take the lead in showing that the development of the pathophysiology of CKD may also cause or exacerbate AD, especially the renin-angiotensin system (RAS). In vivo studies had already shown that the increased expression of angiotensin-converting enzyme (ACE) produces a positive effect in aggravating AD, but ACE inhibitors (ACEIs) have protective effects against AD. Among the possible association of risk factors in CKD and AD, we mainly discuss the RAS in the systemic circulation and the brain.https://www.mdpi.com/2077-0383/12/4/1459renin-angiotensin systemchronic kidney diseaseAlzheimer’s disease |
| spellingShingle | Ke Ma Zi-Run Zheng Yu Meng Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System Journal of Clinical Medicine renin-angiotensin system chronic kidney disease Alzheimer’s disease |
| title | Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System |
| title_full | Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System |
| title_fullStr | Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System |
| title_full_unstemmed | Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System |
| title_short | Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System |
| title_sort | pathogenesis of chronic kidney disease is closely bound up with alzheimer s disease especially via the renin angiotensin system |
| topic | renin-angiotensin system chronic kidney disease Alzheimer’s disease |
| url | https://www.mdpi.com/2077-0383/12/4/1459 |
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