New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series
Abstract Background Indocyanine Green (ICG) fluorescence-guided surgery is widely used for intraoperative visualization of lymphatic structures. To date, there are no reports indicating this dye being used in lymph node biopsies for suspected or relapsed lymphoma. Methods Between October 2021 and Ju...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-023-02152-x |
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| author | Marco Casaccia Adalberto Ibatici Filippo Ballerini Nicolò Maria Barabino Matteo Santoliquido Franco De Cian |
| author_facet | Marco Casaccia Adalberto Ibatici Filippo Ballerini Nicolò Maria Barabino Matteo Santoliquido Franco De Cian |
| author_sort | Marco Casaccia |
| collection | DOAJ |
| description | Abstract Background Indocyanine Green (ICG) fluorescence-guided surgery is widely used for intraoperative visualization of lymphatic structures. To date, there are no reports indicating this dye being used in lymph node biopsies for suspected or relapsed lymphoma. Methods Between October 2021 and June 2022, 12 patients underwent a fluorescence-guided laparoscopic lymph node biopsy (FGLLB) using ICG. The following was retrospectively evaluated: the dosage of ICG, the injection site, the number of patients where fluorescence was obtained after ICG administration, and additionally, the parameters indicating the outcome of the surgical procedure. Results The median duration of the surgery was 90 min. A laparotomy conversion was required in one case due to bleeding. Fluorescence was obtained in 10/12 (83.3%) patients by means of subcutaneous/perilesional injection in six of the patients, and intravenously in the other four. Hospitalization had a mean duration of three days. There were no major postoperative complications. FGLLB was used in seven patients to follow lymphoproliferative disease progression, and in five patients to establish a diagnosis. In all cases, FGLLB provided the information necessary for the correct diagnosis. Conclusions Fluorescence with ICG offers a simple and safe method for detecting pathological lymph nodes. FGLLB in suspected intra-abdominal lymphoma can largely benefit from this new opportunity which has not yet been tested to date. Further studies with large case series are needed to confirm its efficacy. |
| first_indexed | 2024-03-10T22:22:39Z |
| format | Article |
| id | doaj.art-db30d3b700f24036a0cbd0e3ebfd7be8 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-03-10T22:22:39Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-db30d3b700f24036a0cbd0e3ebfd7be82023-11-19T12:13:29ZengBMCBMC Surgery1471-24822023-09-012311510.1186/s12893-023-02152-xNew clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case seriesMarco Casaccia0Adalberto Ibatici1Filippo Ballerini2Nicolò Maria Barabino3Matteo Santoliquido4Franco De Cian5Department of Surgical Sciences and Integrated Diagnostics (DISC), University of GenoaHaematology and Transplant Centre Division, IRCCS San Martino HospitalDepartment of Internal Medicine (DiMI), University of GenoaDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of GenoaSurgical Clinic I Unit, IRCCS San Martino HospitalDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of GenoaAbstract Background Indocyanine Green (ICG) fluorescence-guided surgery is widely used for intraoperative visualization of lymphatic structures. To date, there are no reports indicating this dye being used in lymph node biopsies for suspected or relapsed lymphoma. Methods Between October 2021 and June 2022, 12 patients underwent a fluorescence-guided laparoscopic lymph node biopsy (FGLLB) using ICG. The following was retrospectively evaluated: the dosage of ICG, the injection site, the number of patients where fluorescence was obtained after ICG administration, and additionally, the parameters indicating the outcome of the surgical procedure. Results The median duration of the surgery was 90 min. A laparotomy conversion was required in one case due to bleeding. Fluorescence was obtained in 10/12 (83.3%) patients by means of subcutaneous/perilesional injection in six of the patients, and intravenously in the other four. Hospitalization had a mean duration of three days. There were no major postoperative complications. FGLLB was used in seven patients to follow lymphoproliferative disease progression, and in five patients to establish a diagnosis. In all cases, FGLLB provided the information necessary for the correct diagnosis. Conclusions Fluorescence with ICG offers a simple and safe method for detecting pathological lymph nodes. FGLLB in suspected intra-abdominal lymphoma can largely benefit from this new opportunity which has not yet been tested to date. Further studies with large case series are needed to confirm its efficacy.https://doi.org/10.1186/s12893-023-02152-xIndocyanine greenFluorescenceBiopsyLaparoscopyLymphoma |
| spellingShingle | Marco Casaccia Adalberto Ibatici Filippo Ballerini Nicolò Maria Barabino Matteo Santoliquido Franco De Cian New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series BMC Surgery Indocyanine green Fluorescence Biopsy Laparoscopy Lymphoma |
| title | New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series |
| title_full | New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series |
| title_fullStr | New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series |
| title_full_unstemmed | New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series |
| title_short | New clinical application of indocyanine green in fluorescence-guided laparoscopic lymph-node biopsy in case of lymphoma. Preliminary results on a case series |
| title_sort | new clinical application of indocyanine green in fluorescence guided laparoscopic lymph node biopsy in case of lymphoma preliminary results on a case series |
| topic | Indocyanine green Fluorescence Biopsy Laparoscopy Lymphoma |
| url | https://doi.org/10.1186/s12893-023-02152-x |
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