Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.
To evaluate the performance of low contrast media (CM) dose dual-energy computed tomography pulmonary angiography (CTPA) with advanced monoenergetic reconstructions in patients with suspected pulmonary embolism (PE).The study had institutional review board approval; all patients gave written informe...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5132396?pdf=render |
| _version_ | 1818947851769610240 |
|---|---|
| author | Andreas Meier Kai Higashigaito Katharina Martini Moritz Wurnig Burkhardt Seifert Dagmar I Keller Thomas Frauenfelder Hatem Alkadhi |
| author_facet | Andreas Meier Kai Higashigaito Katharina Martini Moritz Wurnig Burkhardt Seifert Dagmar I Keller Thomas Frauenfelder Hatem Alkadhi |
| author_sort | Andreas Meier |
| collection | DOAJ |
| description | To evaluate the performance of low contrast media (CM) dose dual-energy computed tomography pulmonary angiography (CTPA) with advanced monoenergetic reconstructions in patients with suspected pulmonary embolism (PE).The study had institutional review board approval; all patients gave written informed consent. Forty-one patients (25 men, 16 women, mean age 62.9±14.7 years) undergoing low CM dose (15ml, 6g iodine) dual-energy CTPA with advanced monoenergetic reconstructions were matched via propensity-scoring based on logistic regression analysis with a comparison group of 41 patients (24 men, 17 women, mean age 62.7±13.9 years) undergoing standard CM dose single-energy CTPA (80ml, 24g iodine). Subjective (noise, artifacts) and objective (attenuation, noise, contrast-to-noise ratio (CNR)) image quality was assessed by two blinded, independent readers. All patients underwent clinical follow-up after three months for evaluation of adverse events.Interrater agreement for subjective image quality in both groups ranged from fair to excellent (ICC: 0.46-0.84); agreement for objective image quality was excellent (ICC: 0.83-0.93). There was no significant difference regarding subjective noise (p = 0.15-0.72) and artifacts (p = 0.16-1) between the low and the standard CM dose group. There was no significant difference regarding CNR between the CM dose groups (p = 0.11-0.87). Seven of the 41 (17%) patients in the low and 5/41 (12%) in the standard CM dose group were diagnosed with PE (p = 0.32). No patient suffered from subsequent PE or PE-associated death during the follow-up period.Dual-energy CTPA with advanced monoenergetic reconstruction is feasible with 6g iodine and allows for the diagnosis and safe exclusion of central, lobar, and segmental PE. |
| first_indexed | 2024-12-20T08:37:29Z |
| format | Article |
| id | doaj.art-db31429ddb164784a910303c5c6c3d43 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T08:37:29Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-db31429ddb164784a910303c5c6c3d432022-12-21T19:46:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016721410.1371/journal.pone.0167214Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.Andreas MeierKai HigashigaitoKatharina MartiniMoritz WurnigBurkhardt SeifertDagmar I KellerThomas FrauenfelderHatem AlkadhiTo evaluate the performance of low contrast media (CM) dose dual-energy computed tomography pulmonary angiography (CTPA) with advanced monoenergetic reconstructions in patients with suspected pulmonary embolism (PE).The study had institutional review board approval; all patients gave written informed consent. Forty-one patients (25 men, 16 women, mean age 62.9±14.7 years) undergoing low CM dose (15ml, 6g iodine) dual-energy CTPA with advanced monoenergetic reconstructions were matched via propensity-scoring based on logistic regression analysis with a comparison group of 41 patients (24 men, 17 women, mean age 62.7±13.9 years) undergoing standard CM dose single-energy CTPA (80ml, 24g iodine). Subjective (noise, artifacts) and objective (attenuation, noise, contrast-to-noise ratio (CNR)) image quality was assessed by two blinded, independent readers. All patients underwent clinical follow-up after three months for evaluation of adverse events.Interrater agreement for subjective image quality in both groups ranged from fair to excellent (ICC: 0.46-0.84); agreement for objective image quality was excellent (ICC: 0.83-0.93). There was no significant difference regarding subjective noise (p = 0.15-0.72) and artifacts (p = 0.16-1) between the low and the standard CM dose group. There was no significant difference regarding CNR between the CM dose groups (p = 0.11-0.87). Seven of the 41 (17%) patients in the low and 5/41 (12%) in the standard CM dose group were diagnosed with PE (p = 0.32). No patient suffered from subsequent PE or PE-associated death during the follow-up period.Dual-energy CTPA with advanced monoenergetic reconstruction is feasible with 6g iodine and allows for the diagnosis and safe exclusion of central, lobar, and segmental PE.http://europepmc.org/articles/PMC5132396?pdf=render |
| spellingShingle | Andreas Meier Kai Higashigaito Katharina Martini Moritz Wurnig Burkhardt Seifert Dagmar I Keller Thomas Frauenfelder Hatem Alkadhi Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study. PLoS ONE |
| title | Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study. |
| title_full | Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study. |
| title_fullStr | Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study. |
| title_full_unstemmed | Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study. |
| title_short | Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study. |
| title_sort | dual energy ct pulmonary angiography with 6g iodine a propensity score matched study |
| url | http://europepmc.org/articles/PMC5132396?pdf=render |
| work_keys_str_mv | AT andreasmeier dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT kaihigashigaito dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT katharinamartini dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT moritzwurnig dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT burkhardtseifert dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT dagmarikeller dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT thomasfrauenfelder dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy AT hatemalkadhi dualenergyctpulmonaryangiographywith6giodineapropensityscorematchedstudy |