NaF-PET Imaging of Atherosclerosis Burden
The method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of art...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Imaging |
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| Online Access: | https://www.mdpi.com/2313-433X/9/2/31 |
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| author | Poul F. Høilund-Carlsen Reza Piri Oke Gerke Michael Sturek Thomas J. Werner Mona-Elisabeth Revheim Abass Alavi |
| author_facet | Poul F. Høilund-Carlsen Reza Piri Oke Gerke Michael Sturek Thomas J. Werner Mona-Elisabeth Revheim Abass Alavi |
| author_sort | Poul F. Høilund-Carlsen |
| collection | DOAJ |
| description | The method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of arterial wall macrocalcification detectable by CT. However, this method has not yet found its place in the clinical routine. The more exact association between NaF uptake and future arterial calcification is not fully understood, and it remains unclear to what extent NaF-PET may replace or significantly improve clinical cardiovascular risk scoring. The first 10 years of publications in the field were characterized by heterogeneity at multiple levels, and it is not clear how the method may contribute to triage and management of patients with atherosclerosis, including monitoring effects of anti-atherosclerosis intervention. The present review summarizes findings from the recent 2¾ years including the ability of NaF-PET imaging to assess disease progress and evaluate response to treatment. Despite valuable new information, pertinent questions remain unanswered, not least due to a pronounced lack of standardization within the field and of well-designed long-term studies illuminating the natural history of atherosclerosis and effects of intervention. |
| first_indexed | 2024-03-11T08:36:52Z |
| format | Article |
| id | doaj.art-db32e2e0c3a6435b8bd2d4b255cc8578 |
| institution | Directory Open Access Journal |
| issn | 2313-433X |
| language | English |
| last_indexed | 2024-03-11T08:36:52Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Imaging |
| spelling | doaj.art-db32e2e0c3a6435b8bd2d4b255cc85782023-11-16T21:25:03ZengMDPI AGJournal of Imaging2313-433X2023-01-01923110.3390/jimaging9020031NaF-PET Imaging of Atherosclerosis BurdenPoul F. Høilund-Carlsen0Reza Piri1Oke Gerke2Michael Sturek3Thomas J. Werner4Mona-Elisabeth Revheim5Abass Alavi6Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, DenmarkDepartment of Nuclear Medicine, Odense University Hospital, 5000 Odense, DenmarkDepartment of Nuclear Medicine, Odense University Hospital, 5000 Odense, DenmarkDepartment of Anatomy, Cell Biology, Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADivision of Radiology and Nuclear Medicine, Oslo University Hospital, 0424 Oslo, NorwayDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAThe method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of arterial wall macrocalcification detectable by CT. However, this method has not yet found its place in the clinical routine. The more exact association between NaF uptake and future arterial calcification is not fully understood, and it remains unclear to what extent NaF-PET may replace or significantly improve clinical cardiovascular risk scoring. The first 10 years of publications in the field were characterized by heterogeneity at multiple levels, and it is not clear how the method may contribute to triage and management of patients with atherosclerosis, including monitoring effects of anti-atherosclerosis intervention. The present review summarizes findings from the recent 2¾ years including the ability of NaF-PET imaging to assess disease progress and evaluate response to treatment. Despite valuable new information, pertinent questions remain unanswered, not least due to a pronounced lack of standardization within the field and of well-designed long-term studies illuminating the natural history of atherosclerosis and effects of intervention.https://www.mdpi.com/2313-433X/9/2/31atherosclerosisdisease progression18F-sodium fluorideinterventionNaFPET/CT |
| spellingShingle | Poul F. Høilund-Carlsen Reza Piri Oke Gerke Michael Sturek Thomas J. Werner Mona-Elisabeth Revheim Abass Alavi NaF-PET Imaging of Atherosclerosis Burden Journal of Imaging atherosclerosis disease progression 18F-sodium fluoride intervention NaF PET/CT |
| title | NaF-PET Imaging of Atherosclerosis Burden |
| title_full | NaF-PET Imaging of Atherosclerosis Burden |
| title_fullStr | NaF-PET Imaging of Atherosclerosis Burden |
| title_full_unstemmed | NaF-PET Imaging of Atherosclerosis Burden |
| title_short | NaF-PET Imaging of Atherosclerosis Burden |
| title_sort | naf pet imaging of atherosclerosis burden |
| topic | atherosclerosis disease progression 18F-sodium fluoride intervention NaF PET/CT |
| url | https://www.mdpi.com/2313-433X/9/2/31 |
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