Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML)
t(8;21)(q22;q22) is present in ~5–10% of patients with de novo acute myeloid leukemia (AML) and is associated with a better overall prognosis. Variants of the t(8;21) have been described in the literature, however, their clinical and prognostic significance has not been well-characterized. Molecular...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01016/full |
| _version_ | 1828835381346304000 |
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| author | Lindsay Wilde Jillian Cooper Zi-Xuan Wang Zi-Xuan Wang Jinglan Liu |
| author_facet | Lindsay Wilde Jillian Cooper Zi-Xuan Wang Zi-Xuan Wang Jinglan Liu |
| author_sort | Lindsay Wilde |
| collection | DOAJ |
| description | t(8;21)(q22;q22) is present in ~5–10% of patients with de novo acute myeloid leukemia (AML) and is associated with a better overall prognosis. Variants of the t(8;21) have been described in the literature, however, their clinical and prognostic significance has not been well-characterized. Molecular profiling of these cases has not previously been reported but may be useful in better defining the prognosis of this subset of patients. We present two cases of variant t(8;21) AML including clinical, cytogenetic, and molecular data. |
| first_indexed | 2024-12-12T18:00:58Z |
| format | Article |
| id | doaj.art-db32e7aad06c4dc5b5c260a06c673f0a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T18:00:58Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-db32e7aad06c4dc5b5c260a06c673f0a2022-12-22T00:16:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-10-01910.3389/fonc.2019.01016473019Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML)Lindsay Wilde0Jillian Cooper1Zi-Xuan Wang2Zi-Xuan Wang3Jinglan Liu4Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United StatesDepartment of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, United StatesDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA, United StatesDepartment of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, United StatesDepartment of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA, United Statest(8;21)(q22;q22) is present in ~5–10% of patients with de novo acute myeloid leukemia (AML) and is associated with a better overall prognosis. Variants of the t(8;21) have been described in the literature, however, their clinical and prognostic significance has not been well-characterized. Molecular profiling of these cases has not previously been reported but may be useful in better defining the prognosis of this subset of patients. We present two cases of variant t(8;21) AML including clinical, cytogenetic, and molecular data.https://www.frontiersin.org/article/10.3389/fonc.2019.01016/fullacute myeloid leukemiat(8;21)cytogeneticscore binding factorvariant |
| spellingShingle | Lindsay Wilde Jillian Cooper Zi-Xuan Wang Zi-Xuan Wang Jinglan Liu Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) Frontiers in Oncology acute myeloid leukemia t(8;21) cytogenetics core binding factor variant |
| title | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |
| title_full | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |
| title_fullStr | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |
| title_full_unstemmed | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |
| title_short | Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML) |
| title_sort | clinical cytogenetic and molecular findings in two cases of variant t 8 21 acute myeloid leukemia aml |
| topic | acute myeloid leukemia t(8;21) cytogenetics core binding factor variant |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01016/full |
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