A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity

A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity

Pancreatic cancer remains one of the cancers with the poorest prognosis bearing an overall 5-year survival rate of about 5%. Efficient new chemotherapic drugs are still highly desired. Here, bruceine A, a quassinoid identified from the dried fruits of Brucea javanica (L.) Merr., displayed the most p...

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Bibliographic Details
Main Authors:	Cai Lu, Lu Fan, Peng-Fei Zhang, Wei-Wei Tao, Cheng-Bin Yang, Er-Xin Shang, Fei-Yan Chen, Chun-Tao Che, Hai-Bo Cheng, Jin-Ao Duan, Ming Zhao
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Computational and Structural Biotechnology Journal
Subjects:	Quassinoids Bruceine A Phosphoproteomic P38α MAPK activator Binding affinity Molecular simulations
Online Access:	http://www.sciencedirect.com/science/article/pii/S200103702100249X

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