Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging
Skin aging is an unavoidable aspect of human life. Premature skin aging can result from poor care, environmental pollutants, and ultraviolet radiation exposure. Wrinkles, lines, spots, uneven skin tone, and pigmentation are often indicators of skin aging. One cannot avoid aging but cosmetics and pha...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-02-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383511001079 |
| _version_ | 1818253314256535552 |
|---|---|
| author | Sushil Raut Santosh Singh Bhadoriya Vaibhav Uplanchiwar Vijay Mishra Avinash Gahane Sunil Kumar Jain |
| author_facet | Sushil Raut Santosh Singh Bhadoriya Vaibhav Uplanchiwar Vijay Mishra Avinash Gahane Sunil Kumar Jain |
| author_sort | Sushil Raut |
| collection | DOAJ |
| description | Skin aging is an unavoidable aspect of human life. Premature skin aging can result from poor care, environmental pollutants, and ultraviolet radiation exposure. Wrinkles, lines, spots, uneven skin tone, and pigmentation are often indicators of skin aging. One cannot avoid aging but cosmetics and pharmaceutical approaches can minimize and delay the damage. Topical applications of biocompatible and biodegradable vehicles have been explored for delivering anti-aging compounds. Lecithin organogel (LO) is an effective vehicle for topical delivery of many bioactive agents used in aging treatment. Lecithin is cell component isolated from soya beans or eggs and purified to show excellent gelation in non-polar solvents when combined with water. LO can form a heat-stable, resistant to microbial growth, visco-elastic, optically transparent, and non-birefringent micellar system. It serves as an organic medium to enhance dermal permeation of poorly permeable drugs by effectively partitioning into the skin. Its ability to dissolve in hydrophilic as well as in lipophilic drugs makes it a dynamic vehicle, which can be explored as a carrier for anti-aging agents. |
| first_indexed | 2024-12-12T16:38:06Z |
| format | Article |
| id | doaj.art-db33b835db5d497186a780814dcb8ae1 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-12T16:38:06Z |
| publishDate | 2012-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-db33b835db5d497186a780814dcb8ae12022-12-22T00:18:38ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432012-02-012181510.1016/j.apsb.2011.12.005Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin agingSushil Raut0Santosh Singh Bhadoriya1Vaibhav Uplanchiwar2Vijay Mishra3Avinash Gahane4Sunil Kumar Jain5Department of Pharmacy, Adina Institute of Pharmaceutical Sciences, Sagar 470002, IndiaDepartment of Pharmacy, Adina Institute of Pharmaceutical Sciences, Sagar 470002, IndiaDepartment of Pharmacy, Adina Institute of Pharmaceutical Sciences, Sagar 470002, IndiaDepartment of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar 470003, IndiaDepartment of Pharmacy, Adina Institute of Pharmaceutical Sciences, Sagar 470002, IndiaDepartment of Pharmacy, Adina Institute of Pharmaceutical Sciences, Sagar 470002, IndiaSkin aging is an unavoidable aspect of human life. Premature skin aging can result from poor care, environmental pollutants, and ultraviolet radiation exposure. Wrinkles, lines, spots, uneven skin tone, and pigmentation are often indicators of skin aging. One cannot avoid aging but cosmetics and pharmaceutical approaches can minimize and delay the damage. Topical applications of biocompatible and biodegradable vehicles have been explored for delivering anti-aging compounds. Lecithin organogel (LO) is an effective vehicle for topical delivery of many bioactive agents used in aging treatment. Lecithin is cell component isolated from soya beans or eggs and purified to show excellent gelation in non-polar solvents when combined with water. LO can form a heat-stable, resistant to microbial growth, visco-elastic, optically transparent, and non-birefringent micellar system. It serves as an organic medium to enhance dermal permeation of poorly permeable drugs by effectively partitioning into the skin. Its ability to dissolve in hydrophilic as well as in lipophilic drugs makes it a dynamic vehicle, which can be explored as a carrier for anti-aging agents.http://www.sciencedirect.com/science/article/pii/S2211383511001079Skin agingTopicalLecithinBiocompatibleOrganogel |
| spellingShingle | Sushil Raut Santosh Singh Bhadoriya Vaibhav Uplanchiwar Vijay Mishra Avinash Gahane Sunil Kumar Jain Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging Acta Pharmaceutica Sinica B Skin aging Topical Lecithin Biocompatible Organogel |
| title | Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging |
| title_full | Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging |
| title_fullStr | Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging |
| title_full_unstemmed | Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging |
| title_short | Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging |
| title_sort | lecithin organogel a unique micellar system for the delivery of bioactive agents in the treatment of skin aging |
| topic | Skin aging Topical Lecithin Biocompatible Organogel |
| url | http://www.sciencedirect.com/science/article/pii/S2211383511001079 |
| work_keys_str_mv | AT sushilraut lecithinorganogelauniquemicellarsystemforthedeliveryofbioactiveagentsinthetreatmentofskinaging AT santoshsinghbhadoriya lecithinorganogelauniquemicellarsystemforthedeliveryofbioactiveagentsinthetreatmentofskinaging AT vaibhavuplanchiwar lecithinorganogelauniquemicellarsystemforthedeliveryofbioactiveagentsinthetreatmentofskinaging AT vijaymishra lecithinorganogelauniquemicellarsystemforthedeliveryofbioactiveagentsinthetreatmentofskinaging AT avinashgahane lecithinorganogelauniquemicellarsystemforthedeliveryofbioactiveagentsinthetreatmentofskinaging AT sunilkumarjain lecithinorganogelauniquemicellarsystemforthedeliveryofbioactiveagentsinthetreatmentofskinaging |