Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway

Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway

Kurarinone, a flavonoid isolated from the roots of <i>Sophora flavescens</i>, was suggested to exert potent antioxidant and immunosuppressive effects. However, the underlying mechanisms remain unclear. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that...

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Bibliographic Details
Main Authors: Sakiko Nishikawa, Yasumichi Inoue, Yuka Hori, Chiharu Miyajima, Daisuke Morishita, Nobumichi Ohoka, Shigeaki Hida, Toshiaki Makino, Hidetoshi Hayashi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antioxidants
Subjects:
anti-inflammatory
antioxidant
HO-1
KEAP1
kurarinone
Nrf2
Online Access:https://www.mdpi.com/2076-3921/9/9/842

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