Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus
The <i>Yucca</i> genus encompasses about 50 species native to North America. Species within the <i>Yucca</i> genus have been used in traditional medicine to treat pathologies related to inflammation. Despite its historical use and the popular notion of its antioxidant and ant...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/574 |
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| author | Erick Bahena Culhuac Aristide Maggiolino Mona M. M. Y. Elghandour Pasquale De Palo Abdelfattah Z. M. Salem |
| author_facet | Erick Bahena Culhuac Aristide Maggiolino Mona M. M. Y. Elghandour Pasquale De Palo Abdelfattah Z. M. Salem |
| author_sort | Erick Bahena Culhuac |
| collection | DOAJ |
| description | The <i>Yucca</i> genus encompasses about 50 species native to North America. Species within the <i>Yucca</i> genus have been used in traditional medicine to treat pathologies related to inflammation. Despite its historical use and the popular notion of its antioxidant and anti-inflammatory properties, there is a limited amount of research on this genus. To better understand these properties, this work aimed to analyze phytochemical composition through documentary research. This will provide a better understanding of the molecules and the mechanisms of action that confer such antioxidant and anti-inflammatory properties. About 92 phytochemicals present within the genus have reported antioxidant or anti-inflammatory effects. It has been suggested that the antioxidant and anti-inflammatory properties are mainly generated through its free radical scavenging activity, the inhibition of arachidonic acid metabolism, the decrease in TNF-α (Tumor necrosis factor-α), IL-6 (Interleukin-6), iNOS (Inducible nitric oxide synthase), and IL-1β (Interleukin 1β) concentration, the increase of GPx (Glutathione peroxidase), CAT (Catalase), and SOD (Superoxide dismutase) concentration, and the inhibition of the MAPK (Mitogen-Activated Protein Kinase), and NF-κB (Nuclear factor kappa B), and the activation of the Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway. These studies provide evidence of its use in traditional medicine against pathologies related to inflammation. However, more models and studies are needed to properly understand the activity of most plants within the genus, its potency, and the feasibility of its use to help manage or treat chronic inflammation. |
| first_indexed | 2024-03-11T07:00:58Z |
| format | Article |
| id | doaj.art-db359d61305646b7b3bf9cd154645427 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:00:58Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-db359d61305646b7b3bf9cd1546454272023-11-17T09:16:44ZengMDPI AGAntioxidants2076-39212023-02-0112357410.3390/antiox12030574Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> GenusErick Bahena Culhuac0Aristide Maggiolino1Mona M. M. Y. Elghandour2Pasquale De Palo3Abdelfattah Z. M. Salem4Facultad de Ciencias, Universidad Autónoma del Estado de México, Toluca 50000, Estado de México, MexicoDepartment of Veterinary Medicine, University of Bari A. Moro, 70010 Valenzano, ItalyFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca 50000, Estado de México, MexicoDepartment of Veterinary Medicine, University of Bari A. Moro, 70010 Valenzano, ItalyFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca 50000, Estado de México, MexicoThe <i>Yucca</i> genus encompasses about 50 species native to North America. Species within the <i>Yucca</i> genus have been used in traditional medicine to treat pathologies related to inflammation. Despite its historical use and the popular notion of its antioxidant and anti-inflammatory properties, there is a limited amount of research on this genus. To better understand these properties, this work aimed to analyze phytochemical composition through documentary research. This will provide a better understanding of the molecules and the mechanisms of action that confer such antioxidant and anti-inflammatory properties. About 92 phytochemicals present within the genus have reported antioxidant or anti-inflammatory effects. It has been suggested that the antioxidant and anti-inflammatory properties are mainly generated through its free radical scavenging activity, the inhibition of arachidonic acid metabolism, the decrease in TNF-α (Tumor necrosis factor-α), IL-6 (Interleukin-6), iNOS (Inducible nitric oxide synthase), and IL-1β (Interleukin 1β) concentration, the increase of GPx (Glutathione peroxidase), CAT (Catalase), and SOD (Superoxide dismutase) concentration, and the inhibition of the MAPK (Mitogen-Activated Protein Kinase), and NF-κB (Nuclear factor kappa B), and the activation of the Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway. These studies provide evidence of its use in traditional medicine against pathologies related to inflammation. However, more models and studies are needed to properly understand the activity of most plants within the genus, its potency, and the feasibility of its use to help manage or treat chronic inflammation.https://www.mdpi.com/2076-3921/12/3/574<i>Yucca</i> genusethnobotanyphytochemicalsanti-inflammatoryantioxidant |
| spellingShingle | Erick Bahena Culhuac Aristide Maggiolino Mona M. M. Y. Elghandour Pasquale De Palo Abdelfattah Z. M. Salem Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus Antioxidants <i>Yucca</i> genus ethnobotany phytochemicals anti-inflammatory antioxidant |
| title | Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus |
| title_full | Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus |
| title_fullStr | Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus |
| title_full_unstemmed | Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus |
| title_short | Antioxidant and Anti-Inflammatory Properties of Phytochemicals Found in the <i>Yucca</i> Genus |
| title_sort | antioxidant and anti inflammatory properties of phytochemicals found in the i yucca i genus |
| topic | <i>Yucca</i> genus ethnobotany phytochemicals anti-inflammatory antioxidant |
| url | https://www.mdpi.com/2076-3921/12/3/574 |
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