A role for the cannabinoid 1 receptor in neuronal differentiation of adult spinal cord progenitors in vitro is revealed through pharmacological inhibition and genetic deletion

A role for the cannabinoid 1 receptor in neuronal differentiation of adult spinal cord progenitors in vitro is revealed through pharmacological inhibition and genetic deletion

In contrast to the adult brain, the adult spinal cord is a non-neurogenic environment. Understanding how to manipulate the spinal cord environment to promote the formation of new neurons is an attractive therapeutic strategy for spinal cord injury and disease. The cannabinoid 1 receptor (CB1R) has...

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Bibliographic Details
Main Authors: Alexandra eSideris, Tatiana eBekker, Wai Si eChan, Jose V. Montoya-Gacharna, Thomas J.J. Blanck, Esperanza eRecio-Pinto
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Neuroscience
Subjects:
212-2
ACEA
adult spinal cord cultures
AM251
cannabinoid 1 receptor
CB1 -/-
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00004/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00004/full

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