Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy
Epilepsy is associated with abnormal spatiotemporal changes in resting-state brain connectivity, but how these changes are characterized in interhemispheric coupling remains unclear. This study aimed to characterize frequency-dependent alterations in voxel-wise mirrored homotopic connectivity (VMHC)...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00645/full |
| _version_ | 1818130413780992000 |
|---|---|
| author | Lin Jiang Xuejin Ma Shiguang Li Hongjian Luo Guoming Zhang Yanan Wang Tijiang Zhang |
| author_facet | Lin Jiang Xuejin Ma Shiguang Li Hongjian Luo Guoming Zhang Yanan Wang Tijiang Zhang |
| author_sort | Lin Jiang |
| collection | DOAJ |
| description | Epilepsy is associated with abnormal spatiotemporal changes in resting-state brain connectivity, but how these changes are characterized in interhemispheric coupling remains unclear. This study aimed to characterize frequency-dependent alterations in voxel-wise mirrored homotopic connectivity (VMHC) measured by resting-state functional magnetic resonance imaging (rs-fMRI) in children with idiopathic generalized epilepsy (IGE). Rs-fMRI data were collected in 21 children with IGE and 22 demographically matched children with typical development. We used three resting-state frequency bands (full, 0.01–0.08 Hz; slow-4, 0.027–0.073 Hz; slow-5, 0.01–0.027 Hz) to compute VMHC and locate the significant foci. Voxel-wise p <0.001 and cluster-level p <0.05 cluster-level family-wise error correction was applied. In between-group comparisons, we identified that the full and higher frequency (slow-4) bands showed similar reductions in VMHC including Rolandic operculum, putamen, superior frontal, lateral parietal, middle cingulate, and precuneus in children with IGE. In the lower frequency band (slow-5), we identified specific reductions in VMHC in orbitofrontal and middle temporal gyri in children with IGE. Further analyses on main effects and interaction between group and frequency band suggested significant frequency-dependent changes in VMHC, and no significant interaction was found. The results were generally similar with global brain signal regression. Additional association analysis showed that VMHC in the putamen within the full and slow-4 bands was significantly positively correlated with chronological age in children with IGE, and the same analysis was non-significant in the controls; VMHC in the medial prefrontal region in the slow-4 band was significantly positively correlated with IQ performance sub-score. Our findings suggest that IGE children show frequency-dependent changes in interhemispheric integration that spans regions and systems involving cortical-subcortical, language, and visuomotor processing. Decreased functional coupling within the dorsal striatum may reflect atypical development in children with IGE. |
| first_indexed | 2024-12-11T08:04:39Z |
| format | Article |
| id | doaj.art-db36124331364003bd258249c3a3db73 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T08:04:39Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-db36124331364003bd258249c3a3db732022-12-22T01:15:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-07-011110.3389/fneur.2020.00645518397Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized EpilepsyLin Jiang0Xuejin Ma1Shiguang Li2Hongjian Luo3Guoming Zhang4Yanan Wang5Tijiang Zhang6Department of Radiology, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Radiology, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Radiology, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Radiology, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Radiology, Medical Imaging Center of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Radiology, Medical Imaging Center of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Radiology, Medical Imaging Center of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaEpilepsy is associated with abnormal spatiotemporal changes in resting-state brain connectivity, but how these changes are characterized in interhemispheric coupling remains unclear. This study aimed to characterize frequency-dependent alterations in voxel-wise mirrored homotopic connectivity (VMHC) measured by resting-state functional magnetic resonance imaging (rs-fMRI) in children with idiopathic generalized epilepsy (IGE). Rs-fMRI data were collected in 21 children with IGE and 22 demographically matched children with typical development. We used three resting-state frequency bands (full, 0.01–0.08 Hz; slow-4, 0.027–0.073 Hz; slow-5, 0.01–0.027 Hz) to compute VMHC and locate the significant foci. Voxel-wise p <0.001 and cluster-level p <0.05 cluster-level family-wise error correction was applied. In between-group comparisons, we identified that the full and higher frequency (slow-4) bands showed similar reductions in VMHC including Rolandic operculum, putamen, superior frontal, lateral parietal, middle cingulate, and precuneus in children with IGE. In the lower frequency band (slow-5), we identified specific reductions in VMHC in orbitofrontal and middle temporal gyri in children with IGE. Further analyses on main effects and interaction between group and frequency band suggested significant frequency-dependent changes in VMHC, and no significant interaction was found. The results were generally similar with global brain signal regression. Additional association analysis showed that VMHC in the putamen within the full and slow-4 bands was significantly positively correlated with chronological age in children with IGE, and the same analysis was non-significant in the controls; VMHC in the medial prefrontal region in the slow-4 band was significantly positively correlated with IQ performance sub-score. Our findings suggest that IGE children show frequency-dependent changes in interhemispheric integration that spans regions and systems involving cortical-subcortical, language, and visuomotor processing. Decreased functional coupling within the dorsal striatum may reflect atypical development in children with IGE.https://www.frontiersin.org/article/10.3389/fneur.2020.00645/fullfMRIinterhemisphericfunctional connectivityfrequency-dependentIGE |
| spellingShingle | Lin Jiang Xuejin Ma Shiguang Li Hongjian Luo Guoming Zhang Yanan Wang Tijiang Zhang Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy Frontiers in Neurology fMRI interhemispheric functional connectivity frequency-dependent IGE |
| title | Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy |
| title_full | Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy |
| title_fullStr | Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy |
| title_full_unstemmed | Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy |
| title_short | Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy |
| title_sort | frequency dependent changes in interhemispheric functional connectivity measured by resting state fmri in children with idiopathic generalized epilepsy |
| topic | fMRI interhemispheric functional connectivity frequency-dependent IGE |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00645/full |
| work_keys_str_mv | AT linjiang frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy AT xuejinma frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy AT shiguangli frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy AT hongjianluo frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy AT guomingzhang frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy AT yananwang frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy AT tijiangzhang frequencydependentchangesininterhemisphericfunctionalconnectivitymeasuredbyrestingstatefmriinchildrenwithidiopathicgeneralizedepilepsy |