Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica
Abstract Schistosomiasis japonicum can cause different degrees of organ damage and complex human immune pathological reactions, which often invade the intestine and liver. The purpose of this study was to explore the pathological types and pathological changes of Schistosomiasis and their correlatio...
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42456-9 |
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| author | Yang Yang Xiao-Yi Wang Chun Duan Zi-Jian Wang Hao-Yu Sheng Xiu-Liang Xu Wen-Jie Wang Jiang-Hua Yang |
| author_facet | Yang Yang Xiao-Yi Wang Chun Duan Zi-Jian Wang Hao-Yu Sheng Xiu-Liang Xu Wen-Jie Wang Jiang-Hua Yang |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Abstract Schistosomiasis japonicum can cause different degrees of organ damage and complex human immune pathological reactions, which often invade the intestine and liver. The purpose of this study was to explore the pathological types and pathological changes of Schistosomiasis and their correlation with some digestive system tumors. Hematoxylin eosin staining was performed on the diseased tissues of 1111 Schistosomiasis cases. We counted the deposition sites of Schistosoma eggs, analyzed the pathological characteristics, and compared the clinicopathological characteristics of Schistosomiasis associated digestive system tumors and non-Schistosomiasis digestive system tumors. We found that Schistosoma japonicum can cause multi organ and multi system damage, with 469 cases of inflammation, 47 cases of adenoma, and 519 cases of adenocarcinoma. Other types include cysts, stromal tumors, malignant lymphomas, and neuroendocrine tumors. Schistosomiasis associated tumors, including gastric cancer, liver cancer, colon cancer and rectal cancer, were compared with non-Schistosomiasis tumors. There were significant differences in age, gender and tumor differentiation between the two groups. Our study shows Schistosomiasis is a systemic disease, causing multiple organ and system damage in the human body. Its clinicopathological types are diverse, and there may be a pathological change process of “Inflammation-adenoma-carcinoma”. Schistosomiasis associated digestive system tumors differ from non-Schistosomiasis tumors in some clinicopathological features. |
| first_indexed | 2024-03-09T15:17:02Z |
| format | Article |
| id | doaj.art-db37fc604601463eb74efde22d00c3b1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:17:02Z |
| publishDate | 2023-09-01 |
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| series | Scientific Reports |
| spelling | doaj.art-db37fc604601463eb74efde22d00c3b12023-11-26T13:04:09ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-42456-9Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonicaYang Yang0Xiao-Yi Wang1Chun Duan2Zi-Jian Wang3Hao-Yu Sheng4Xiu-Liang Xu5Wen-Jie Wang6Jiang-Hua Yang7Department of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeDepartment of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeDepartment of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeDepartment of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeDepartment of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeDepartment of Infectious Diseases, The People’s Hospital of ChizhouDepartment of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeDepartment of Infectious Diseases, Yijishan Hospital of Wannan Medical CollegeAbstract Schistosomiasis japonicum can cause different degrees of organ damage and complex human immune pathological reactions, which often invade the intestine and liver. The purpose of this study was to explore the pathological types and pathological changes of Schistosomiasis and their correlation with some digestive system tumors. Hematoxylin eosin staining was performed on the diseased tissues of 1111 Schistosomiasis cases. We counted the deposition sites of Schistosoma eggs, analyzed the pathological characteristics, and compared the clinicopathological characteristics of Schistosomiasis associated digestive system tumors and non-Schistosomiasis digestive system tumors. We found that Schistosoma japonicum can cause multi organ and multi system damage, with 469 cases of inflammation, 47 cases of adenoma, and 519 cases of adenocarcinoma. Other types include cysts, stromal tumors, malignant lymphomas, and neuroendocrine tumors. Schistosomiasis associated tumors, including gastric cancer, liver cancer, colon cancer and rectal cancer, were compared with non-Schistosomiasis tumors. There were significant differences in age, gender and tumor differentiation between the two groups. Our study shows Schistosomiasis is a systemic disease, causing multiple organ and system damage in the human body. Its clinicopathological types are diverse, and there may be a pathological change process of “Inflammation-adenoma-carcinoma”. Schistosomiasis associated digestive system tumors differ from non-Schistosomiasis tumors in some clinicopathological features.https://doi.org/10.1038/s41598-023-42456-9 |
| spellingShingle | Yang Yang Xiao-Yi Wang Chun Duan Zi-Jian Wang Hao-Yu Sheng Xiu-Liang Xu Wen-Jie Wang Jiang-Hua Yang Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica Scientific Reports |
| title | Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica |
| title_full | Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica |
| title_fullStr | Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica |
| title_full_unstemmed | Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica |
| title_short | Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica |
| title_sort | clinicopathological characteristics and its association with digestive system tumors of 1111 patients with schistosomiasis japonica |
| url | https://doi.org/10.1038/s41598-023-42456-9 |
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