Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan
This work is devoted to the chemical synthesis of sulfated chitosan and its experimental verification in an animal model of early atherosclerosis. The method of chitosan quaternization with sulfate-containing ingredients resulted in a product with a high content of sulfate groups. Implantation of th...
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MDPI AG
2022-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/16/3431 |
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| author | I. N. Bolshakov L. M. Gornostaev O. I. Fominykh A. V. Svetlakov |
| author_facet | I. N. Bolshakov L. M. Gornostaev O. I. Fominykh A. V. Svetlakov |
| author_sort | I. N. Bolshakov |
| collection | DOAJ |
| description | This work is devoted to the chemical synthesis of sulfated chitosan and its experimental verification in an animal model of early atherosclerosis. The method of chitosan quaternization with sulfate-containing ingredients resulted in a product with a high content of sulfate groups. Implantation of this product into the fascial-muscular sheath of the main limb artery along the leg and thigh in rabbits led to the extraction of cholesterol from the subintimal region. Simplified methods for the chemical synthesis of quaternized sulfated chitosan and the use of these products in a model of experimental atherosclerosis made it possible to perform a comparative morphological analysis of the vascular walls of the experimental and control limbs under conditions of a long-term high-cholesterol diet. The sulfated chitosan samples after implantation were shown to change the morphological pattern of the intimal and middle membranes of the experimental limb artery. The implantation led to the degradation of soft plaques within 30 days after surgical intervention, which significantly increased collateral blood flow. The implantation of sulfated chitosan into the local area of the atherosclerotic lesions in the artery can regulate the cholesterol content in the vascular wall and destroy soft plaques in the subintimal region. |
| first_indexed | 2024-03-09T03:56:00Z |
| format | Article |
| id | doaj.art-db39076d881b4d6484abebe395945bcb |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T03:56:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-db39076d881b4d6484abebe395945bcb2023-12-03T14:20:52ZengMDPI AGPolymers2073-43602022-08-011416343110.3390/polym14163431Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated ChitosanI. N. Bolshakov0L. M. Gornostaev1O. I. Fominykh2A. V. Svetlakov3Department of Operative Surgery and Topographic Anatomy, FSBE Higher Education Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk 660022, RussiaDepartment of Operative Surgery and Topographic Anatomy, FSBE Higher Education Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk 660022, RussiaDepartment of Biology, Chemistry and Ecology, Krasnoyarsk State Pedagogical University Named after V.P. Astafiev, Krasnoyarsk 660049, RussiaAlfaChem Limited Liability Company, Krasnoyarsk 660135, RussiaThis work is devoted to the chemical synthesis of sulfated chitosan and its experimental verification in an animal model of early atherosclerosis. The method of chitosan quaternization with sulfate-containing ingredients resulted in a product with a high content of sulfate groups. Implantation of this product into the fascial-muscular sheath of the main limb artery along the leg and thigh in rabbits led to the extraction of cholesterol from the subintimal region. Simplified methods for the chemical synthesis of quaternized sulfated chitosan and the use of these products in a model of experimental atherosclerosis made it possible to perform a comparative morphological analysis of the vascular walls of the experimental and control limbs under conditions of a long-term high-cholesterol diet. The sulfated chitosan samples after implantation were shown to change the morphological pattern of the intimal and middle membranes of the experimental limb artery. The implantation led to the degradation of soft plaques within 30 days after surgical intervention, which significantly increased collateral blood flow. The implantation of sulfated chitosan into the local area of the atherosclerotic lesions in the artery can regulate the cholesterol content in the vascular wall and destroy soft plaques in the subintimal region.https://www.mdpi.com/2073-4360/14/16/3431organic synthesisO,N-(2-sulfoethyl)chitosansulfated polyelectrolyte complexestransport systemexperimental atherosclerosispara-adventitial implantation |
| spellingShingle | I. N. Bolshakov L. M. Gornostaev O. I. Fominykh A. V. Svetlakov Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan Polymers organic synthesis O,N-(2-sulfoethyl)chitosan sulfated polyelectrolyte complexes transport system experimental atherosclerosis para-adventitial implantation |
| title | Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan |
| title_full | Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan |
| title_fullStr | Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan |
| title_full_unstemmed | Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan |
| title_short | Synthesis, Chemical and Biomedical Aspects of the Use of Sulfated Chitosan |
| title_sort | synthesis chemical and biomedical aspects of the use of sulfated chitosan |
| topic | organic synthesis O,N-(2-sulfoethyl)chitosan sulfated polyelectrolyte complexes transport system experimental atherosclerosis para-adventitial implantation |
| url | https://www.mdpi.com/2073-4360/14/16/3431 |
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