EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation.
Theta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5130195?pdf=render |
| _version_ | 1819066133750218752 |
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| author | Nicole Prause Greg J Siegle Choi Deblieck Allan Wu Marco Iacoboni |
| author_facet | Nicole Prause Greg J Siegle Choi Deblieck Allan Wu Marco Iacoboni |
| author_sort | Nicole Prause |
| collection | DOAJ |
| description | Theta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at least two opposite-sex, sexual partners in the last year received two forms of TBS. Stimulations were randomized to avoid order effects and separated by 2 hours to reduce carryover. The two TBS forms have been demonstrated to inhibit (continuous) or excite (intermittent) the left dorsolateral prefrontal cortex using different pulse patterns, which links to brain areas associated with reward conditioning. After each TBS, participants completed tasks assessing their reward responsiveness to monetary and sexual rewards. Electroencephalography (EEG) was recorded. They also reported their number of orgasms in the weekend following stimulation. This signal was malleable by TBS, where excitatory TBS resulted in lower EEG alpha relative to inhibitory TBS to primary rewards. EEG responses to sexual rewards in the lab (following both forms of TBS) predicted the number of orgasms experienced over the forthcoming weekend. TBS may be useful in modifying hypersensitivity or hyposensitivity to primary rewards that predict sexual behaviors. Since TBS altered the anticipation of a sexual reward, TBS may offer a novel treatment for sexual desire problems. |
| first_indexed | 2024-12-21T15:57:31Z |
| format | Article |
| id | doaj.art-db3956f880624b46bd579abb916a4383 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:57:31Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-db3956f880624b46bd579abb916a43832022-12-21T18:58:04ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016564610.1371/journal.pone.0165646EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation.Nicole PrauseGreg J SiegleChoi DeblieckAllan WuMarco IacoboniTheta burst stimulation (TBS) is thought to affect reward processing mechanisms, which may increase and decrease reward sensitivity. To test the ability of TBS to modulate response to strong primary rewards, participants hypersensitive to primary rewards were recruited. Twenty men and women with at least two opposite-sex, sexual partners in the last year received two forms of TBS. Stimulations were randomized to avoid order effects and separated by 2 hours to reduce carryover. The two TBS forms have been demonstrated to inhibit (continuous) or excite (intermittent) the left dorsolateral prefrontal cortex using different pulse patterns, which links to brain areas associated with reward conditioning. After each TBS, participants completed tasks assessing their reward responsiveness to monetary and sexual rewards. Electroencephalography (EEG) was recorded. They also reported their number of orgasms in the weekend following stimulation. This signal was malleable by TBS, where excitatory TBS resulted in lower EEG alpha relative to inhibitory TBS to primary rewards. EEG responses to sexual rewards in the lab (following both forms of TBS) predicted the number of orgasms experienced over the forthcoming weekend. TBS may be useful in modifying hypersensitivity or hyposensitivity to primary rewards that predict sexual behaviors. Since TBS altered the anticipation of a sexual reward, TBS may offer a novel treatment for sexual desire problems.http://europepmc.org/articles/PMC5130195?pdf=render |
| spellingShingle | Nicole Prause Greg J Siegle Choi Deblieck Allan Wu Marco Iacoboni EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation. PLoS ONE |
| title | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation. |
| title_full | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation. |
| title_fullStr | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation. |
| title_full_unstemmed | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation. |
| title_short | EEG to Primary Rewards: Predictive Utility and Malleability by Brain Stimulation. |
| title_sort | eeg to primary rewards predictive utility and malleability by brain stimulation |
| url | http://europepmc.org/articles/PMC5130195?pdf=render |
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