Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway

Targeting Mechanosensitive Piezo1 Alleviated Renal Fibrosis Through p38MAPK-YAP Pathway

Renal fibrosis is the most common pathological manifestation of a wide variety of chronic kidney disease. Increased extracellular matrix (ECM) secretion and enhanced microenvironment stiffening aggravate the progression of renal fibrosis. However, the related mechanisms remain unclear. Here, we eval...

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Bibliographic Details
Main Authors: Yuanyuan Fu, Pengzhi Wan, Jie Zhang, Xue Li, Jia Xing, Yu Zou, Kaiyue Wang, Hui Peng, Qizhuo Zhu, Liu Cao, Xiaoyue Zhai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
renal fibrosis
matrix stiffness
extracellular matrix secreation
Piezo1
YAP
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.741060/full

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