The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease
It is widely believed that amyloid β⁃protein (Aβ) plays a core role in the pathogenesis of Alzheimer's disease (AD). Thus A β is one of main targets in the therapeutic explorations for AD. Currently, clearance of A β by passive immunotherapy is an important strategy for the treatment of AD. How...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2019-12-01
|
| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2070 |
| _version_ | 1818546929528733696 |
|---|---|
| author | Ya LI An⁃ni ZHANG Xu⁃ling WU Yan ZHAO Gang CAI Dian HE |
| author_facet | Ya LI An⁃ni ZHANG Xu⁃ling WU Yan ZHAO Gang CAI Dian HE |
| author_sort | Ya LI |
| collection | DOAJ |
| description | It is widely believed that amyloid β⁃protein (Aβ) plays a core role in the pathogenesis of Alzheimer's disease (AD). Thus A β is one of main targets in the therapeutic explorations for AD. Currently, clearance of A β by passive immunotherapy is an important strategy for the treatment of AD. However, no consistent conclusions have been obtained from various clinical trails. We summarize the current situations of A β⁃directed passive immunotherapy for AD, and speculate that the failure of A β⁃directed passive immunotherapy for AD may be related to the intrinsic characteristics of A β⁃IgG glycosylation. Therefore, modifications of N ⁃ glycosylation on the Fc domain of A β⁃IgG and using a sequential administration mode of proinflammation⁃antiinflammation may be an effective strategy for passive immunotherapy for AD.
DOI：10.3969/j.issn.1672⁃6731.2019.12.014 |
| first_indexed | 2024-12-12T07:59:48Z |
| format | Article |
| id | doaj.art-db3bc2befe0b4f76b791dae2ec0c52b6 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-12T07:59:48Z |
| publishDate | 2019-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-db3bc2befe0b4f76b791dae2ec0c52b62022-12-22T00:32:11ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312019-12-0119129879932025The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's diseaseYa LIAn⁃ni ZHANGXu⁃ling WUYan ZHAOGang CAIDian HEIt is widely believed that amyloid β⁃protein (Aβ) plays a core role in the pathogenesis of Alzheimer's disease (AD). Thus A β is one of main targets in the therapeutic explorations for AD. Currently, clearance of A β by passive immunotherapy is an important strategy for the treatment of AD. However, no consistent conclusions have been obtained from various clinical trails. We summarize the current situations of A β⁃directed passive immunotherapy for AD, and speculate that the failure of A β⁃directed passive immunotherapy for AD may be related to the intrinsic characteristics of A β⁃IgG glycosylation. Therefore, modifications of N ⁃ glycosylation on the Fc domain of A β⁃IgG and using a sequential administration mode of proinflammation⁃antiinflammation may be an effective strategy for passive immunotherapy for AD. DOI：10.3969/j.issn.1672⁃6731.2019.12.014http://www.cjcnn.org/index.php/cjcnn/article/view/2070alzheimer diseaseamyloid beta⁃peptidesimmunization, passivereview |
| spellingShingle | Ya LI An⁃ni ZHANG Xu⁃ling WU Yan ZHAO Gang CAI Dian HE The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease Chinese Journal of Contemporary Neurology and Neurosurgery alzheimer disease amyloid beta⁃peptides immunization, passive review |
| title | The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease |
| title_full | The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease |
| title_fullStr | The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease |
| title_full_unstemmed | The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease |
| title_short | The situations and strategies of amyloid⁃β⁃directed passive immunotherapy for Alzheimer's disease |
| title_sort | situations and strategies of amyloid⁃β⁃directed passive immunotherapy for alzheimer s disease |
| topic | alzheimer disease amyloid beta⁃peptides immunization, passive review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2070 |
| work_keys_str_mv | AT yali thesituationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT annizhang thesituationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT xulingwu thesituationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT yanzhao thesituationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT gangcai thesituationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT dianhe thesituationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT yali situationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT annizhang situationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT xulingwu situationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT yanzhao situationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT gangcai situationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease AT dianhe situationsandstrategiesofamyloidbdirectedpassiveimmunotherapyforalzheimersdisease |