| Resumo: | Over the past decade, significant progress has been made in the
understanding of the molecular biology of cytomegalovirus (CMV) and the pathogenesis of CMV infection
and disease. The introduction of antiviral agents with efficacy against CMV, coupled with rapid diagnostic
techniques in the laboratory, have resulted in the design of a number of regimens lo prevent, modify and
treat CMV infections in transplant recipients. Strategies for preventing CMV infection, including donorrecipient
matching, the use of CMV 'safe' cellular blood products, passive and active immunization, and
prophylactic antiviral drugs are discussed. Clinical trials of antiviral drugs alone. or in combination with
immunoglobulin for the treatment of CMV disease are reviewed.
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