DYRK1A: A master regulatory protein controlling brain growth

DYRK1A: A master regulatory protein controlling brain growth

Copy number variation in a small region of chromosome 21 containing DYRK1A produces morphological and cognitive alterations in human. In mouse models, haploinsufficiency results in microcephaly, and a human DYRK1A gain-of-function model (three alleles) exhibits increased brain volume. To investigate...

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Bibliographic Details
Main Authors:	Fayçal Guedj, Patricia Lopes Pereira, Sonia Najas, Maria-Jose Barallobre, Caroline Chabert, Benoit Souchet, Catherine Sebrie, Catherine Verney, Yann Herault, Mariona Arbones, Jean M. Delabar
Format:	Article
Language:	English
Published:	Elsevier 2012-04-01
Series:	Neurobiology of Disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996112000228

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