siRNAs Targeting Growth Factor Receptor and Anti-Apoptotic Genes Synergistically Kill Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways

siRNAs Targeting Growth Factor Receptor and Anti-Apoptotic Genes Synergistically Kill Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways

Breast cancer, the second leading cause of female deaths worldwide, is usually treated with cytotoxic drugs, accompanied by adverse side-effects, development of chemoresistance and relapse of disease condition. Survival and proliferation of the cancer cells are greatly empowered by over-expression o...

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Bibliographic Details
Main Authors: Nur Izyani Kamaruzman, Snigdha Tiash, Maeirah Ashaie, Ezharul Hoque Chowdhury
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Biomedicines
Subjects:
carbonate apatite nanoparticle
siRNA
estrogen receptor (ER)
mitogen-activated protein kinase (MAPK)
protein kinase B (AKT)
breast cancer
Online Access:http://www.mdpi.com/2227-9059/6/3/73

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