Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity
Airway epithelial cells are the first line of defense against the constituents of the inhaled air, which include allergens, pathogens, pollutants and toxic compounds. The epithelium not only prevents the penetration of these foreign substances into the interstitium, but also senses their presence an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00147/full |
| _version_ | 1819143757344276480 |
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| author | Vivek Dipak Gandhi Harissios eVliagoftis |
| author_facet | Vivek Dipak Gandhi Harissios eVliagoftis |
| author_sort | Vivek Dipak Gandhi |
| collection | DOAJ |
| description | Airway epithelial cells are the first line of defense against the constituents of the inhaled air, which include allergens, pathogens, pollutants and toxic compounds. The epithelium not only prevents the penetration of these foreign substances into the interstitium, but also senses their presence and informs the organism’s immune system of the impending assault. Epithelium accomplishes the latter through the release of inflammatory cytokines and chemokines that recruit and activate innate immune cells at the site of assault. These epithelial responses aim to eliminate the inhaled foreign substances and minimize their detrimental effects to the organism. Quite frequently, however, these innate immune responses of the epithelium to inhaled substances may become self-damaging because of chronic and high level release of pro-inflammatory mediators. The interactions of airway epithelial cells with allergens will be discussed with particular focus in the interactions-mediated epithelial release of cytokines-chemokines and their role in the immune response. As pollutants are other major constituents of inhaled air, we will also discuss how pollutants may alter the responses of airway epithelial cells to allergens. |
| first_indexed | 2024-12-22T12:31:19Z |
| format | Article |
| id | doaj.art-db3e3e7f10184ec6a1fc16ea6a3e1497 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T12:31:19Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-db3e3e7f10184ec6a1fc16ea6a3e14972022-12-21T18:25:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242015-04-01610.3389/fimmu.2015.00147119348Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunityVivek Dipak Gandhi0Harissios eVliagoftis1University of AlbertaUniversity of AlbertaAirway epithelial cells are the first line of defense against the constituents of the inhaled air, which include allergens, pathogens, pollutants and toxic compounds. The epithelium not only prevents the penetration of these foreign substances into the interstitium, but also senses their presence and informs the organism’s immune system of the impending assault. Epithelium accomplishes the latter through the release of inflammatory cytokines and chemokines that recruit and activate innate immune cells at the site of assault. These epithelial responses aim to eliminate the inhaled foreign substances and minimize their detrimental effects to the organism. Quite frequently, however, these innate immune responses of the epithelium to inhaled substances may become self-damaging because of chronic and high level release of pro-inflammatory mediators. The interactions of airway epithelial cells with allergens will be discussed with particular focus in the interactions-mediated epithelial release of cytokines-chemokines and their role in the immune response. As pollutants are other major constituents of inhaled air, we will also discuss how pollutants may alter the responses of airway epithelial cells to allergens.http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00147/fullinflammatory mediatorsAirway and allergensPollutants and allergensAirway epithelium in asthmaHouse dust mite and airwayCockroach allergens and airway |
| spellingShingle | Vivek Dipak Gandhi Harissios eVliagoftis Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity Frontiers in Immunology inflammatory mediators Airway and allergens Pollutants and allergens Airway epithelium in asthma House dust mite and airway Cockroach allergens and airway |
| title | Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity |
| title_full | Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity |
| title_fullStr | Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity |
| title_full_unstemmed | Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity |
| title_short | Airway epithelium interactions with aeroallergens: Role of secreted cytokines and chemokines in innate immunity |
| title_sort | airway epithelium interactions with aeroallergens role of secreted cytokines and chemokines in innate immunity |
| topic | inflammatory mediators Airway and allergens Pollutants and allergens Airway epithelium in asthma House dust mite and airway Cockroach allergens and airway |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00147/full |
| work_keys_str_mv | AT vivekdipakgandhi airwayepitheliuminteractionswithaeroallergensroleofsecretedcytokinesandchemokinesininnateimmunity AT harissiosevliagoftis airwayepitheliuminteractionswithaeroallergensroleofsecretedcytokinesandchemokinesininnateimmunity |