Evaluation of mean platelet volume in localized scleroderma
Abstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute t...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2017-10-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000500635&tlng=en |
| _version_ | 1818979526207602688 |
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| author | Anil Gulsel Bahali Ozlem Su Nazan Emiroglu Fatma Pelin Cengiz Mehmet Onur Kaya Nahide Onsun |
| author_facet | Anil Gulsel Bahali Ozlem Su Nazan Emiroglu Fatma Pelin Cengiz Mehmet Onur Kaya Nahide Onsun |
| author_sort | Anil Gulsel Bahali |
| collection | DOAJ |
| description | Abstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. Objectives: To evaluate whether there was any relation between localized scleroderma and platelet parameters. Methods: Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. Results: The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01). Study Limitations: The limited number of patients and the retrospective nature of the study were our limitations. Conclusions: This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies. |
| first_indexed | 2024-12-20T17:00:56Z |
| format | Article |
| id | doaj.art-db40666b4b224e3985b561a4fd7ab771 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-20T17:00:56Z |
| publishDate | 2017-10-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-db40666b4b224e3985b561a4fd7ab7712022-12-21T19:32:32ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962017-10-0192563563710.1590/abd1806-4841.20176045Evaluation of mean platelet volume in localized sclerodermaAnil Gulsel BahaliOzlem SuNazan EmirogluFatma Pelin CengizMehmet Onur KayaNahide OnsunAbstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. Objectives: To evaluate whether there was any relation between localized scleroderma and platelet parameters. Methods: Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. Results: The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01). Study Limitations: The limited number of patients and the retrospective nature of the study were our limitations. Conclusions: This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000500635&tlng=enBlood plateletsScleroderma, localizedTransforming growth factor beta |
| spellingShingle | Anil Gulsel Bahali Ozlem Su Nazan Emiroglu Fatma Pelin Cengiz Mehmet Onur Kaya Nahide Onsun Evaluation of mean platelet volume in localized scleroderma Anais Brasileiros de Dermatologia Blood platelets Scleroderma, localized Transforming growth factor beta |
| title | Evaluation of mean platelet volume in localized scleroderma |
| title_full | Evaluation of mean platelet volume in localized scleroderma |
| title_fullStr | Evaluation of mean platelet volume in localized scleroderma |
| title_full_unstemmed | Evaluation of mean platelet volume in localized scleroderma |
| title_short | Evaluation of mean platelet volume in localized scleroderma |
| title_sort | evaluation of mean platelet volume in localized scleroderma |
| topic | Blood platelets Scleroderma, localized Transforming growth factor beta |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000500635&tlng=en |
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