High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study
This study aimed to evaluate the associations of baseline high-sensitivity C-reactive protein (Hs-CRP) and its change with subsequent cognitive decline and cognitive impairment. Data for this study were obtained from the China Health and Retirement Longitudinal Study, a national community-based pros...
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MDPI AG
2023-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/4/658 |
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| author | Yechuang Wang Jialin Fu Fang Liang Theresa M. Oniffrey Kai Ding Jing Zeng Justin B. Moore Xianwu Luo Rui Li |
| author_facet | Yechuang Wang Jialin Fu Fang Liang Theresa M. Oniffrey Kai Ding Jing Zeng Justin B. Moore Xianwu Luo Rui Li |
| author_sort | Yechuang Wang |
| collection | DOAJ |
| description | This study aimed to evaluate the associations of baseline high-sensitivity C-reactive protein (Hs-CRP) and its change with subsequent cognitive decline and cognitive impairment. Data for this study were obtained from the China Health and Retirement Longitudinal Study, a national community-based prospective cohort study. Hs-CRP level and cognitive function were measured repeatedly over a 7-year follow-up. Linear mixed models and cox proportional hazard models were used to evaluate the associations. The study comprised 7385 participants (50.67% women, mean age 59.08 ± 8.86 years) with baseline Hs-CRP ranging from 0.03 to 178.10 mg/L (median: 1.01 mg/L, IQR: 0.55–2.11 mg/L). During a median of 5.79 years follow-up, the highest quartile of the Hs-CRP group showed a faster rate of cognitive decline (−0.0053 SD/year, <i>p</i> = 0.006) and a higher risk of cognitive impairment (HR 1.0814, <i>p</i> = 0.044) than those in the lowest quartile. Individuals in the elevated group of Hs-CRP change had a significantly faster cognitive decline (−0.0070 SD/year, <i>p</i> = 0.016) compared with those in the stable group. In this study, significant longitudinal associations between baseline Hs-CRP, elevated Hs-CRP, and long-term cognitive deterioration were observed. Hs-CRP level could perhaps serve as a predictor for cognitive deterioration in middle-aged and older adults. |
| first_indexed | 2024-03-11T05:11:29Z |
| format | Article |
| id | doaj.art-db4274ee92dc4a92ae5db3c246379a21 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T05:11:29Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-db4274ee92dc4a92ae5db3c246379a212023-11-17T18:33:16ZengMDPI AGBrain Sciences2076-34252023-04-0113465810.3390/brainsci13040658High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort StudyYechuang Wang0Jialin Fu1Fang Liang2Theresa M. Oniffrey3Kai Ding4Jing Zeng5Justin B. Moore6Xianwu Luo7Rui Li8School of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Atrium Health Wake Forest Baptist, Medical Center Boulevard, Winston-Salem, NC 27157, USASchool of Public Health, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaDepartment of Implementation Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USASchool of Nursing, Wuhan University, Wuhan 430071, ChinaSchool of Public Health, Wuhan University, Wuhan 430071, ChinaThis study aimed to evaluate the associations of baseline high-sensitivity C-reactive protein (Hs-CRP) and its change with subsequent cognitive decline and cognitive impairment. Data for this study were obtained from the China Health and Retirement Longitudinal Study, a national community-based prospective cohort study. Hs-CRP level and cognitive function were measured repeatedly over a 7-year follow-up. Linear mixed models and cox proportional hazard models were used to evaluate the associations. The study comprised 7385 participants (50.67% women, mean age 59.08 ± 8.86 years) with baseline Hs-CRP ranging from 0.03 to 178.10 mg/L (median: 1.01 mg/L, IQR: 0.55–2.11 mg/L). During a median of 5.79 years follow-up, the highest quartile of the Hs-CRP group showed a faster rate of cognitive decline (−0.0053 SD/year, <i>p</i> = 0.006) and a higher risk of cognitive impairment (HR 1.0814, <i>p</i> = 0.044) than those in the lowest quartile. Individuals in the elevated group of Hs-CRP change had a significantly faster cognitive decline (−0.0070 SD/year, <i>p</i> = 0.016) compared with those in the stable group. In this study, significant longitudinal associations between baseline Hs-CRP, elevated Hs-CRP, and long-term cognitive deterioration were observed. Hs-CRP level could perhaps serve as a predictor for cognitive deterioration in middle-aged and older adults.https://www.mdpi.com/2076-3425/13/4/658Hs-CRPHs-CRP changecognitive declinecognitive impairment |
| spellingShingle | Yechuang Wang Jialin Fu Fang Liang Theresa M. Oniffrey Kai Ding Jing Zeng Justin B. Moore Xianwu Luo Rui Li High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study Brain Sciences Hs-CRP Hs-CRP change cognitive decline cognitive impairment |
| title | High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study |
| title_full | High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study |
| title_fullStr | High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study |
| title_full_unstemmed | High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study |
| title_short | High-Sensitivity C-Reactive Protein, Its Change, and Cognitive Function: A National Population-Based Cohort Study |
| title_sort | high sensitivity c reactive protein its change and cognitive function a national population based cohort study |
| topic | Hs-CRP Hs-CRP change cognitive decline cognitive impairment |
| url | https://www.mdpi.com/2076-3425/13/4/658 |
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