The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue

Kynurenic acid (KYNA) is a bioactive compound that is produced along the kynurenine pathway (KP) during tryptophan degradation. In a few decades, KYNA shifted from being regarded a poorly characterized by-product of the KP to being considered a main player in many aspects of mammalian physiology, in...

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Bibliographic Details
Main Authors: Franca Rossi, Riccardo Miggiano, Davide M. Ferraris, Menico Rizzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
kynurenine pathway
kynurenic acid
kynurenine aminotransferase
PLP enzyme
crystal structure
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00007/full

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