Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer
Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE)...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/12/765 |
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| author | Simone Cilio Antonio Tufano Gabriele Pezone Pierluigi Alvino Gianluca Spena Savio Domenico Pandolfo Paola Del Prete Claudio Amato Rocco Damiano Andrea Salonia Riccardo Autorino Alessandro Izzo Francesco Passaro Sisto Perdonà |
| author_facet | Simone Cilio Antonio Tufano Gabriele Pezone Pierluigi Alvino Gianluca Spena Savio Domenico Pandolfo Paola Del Prete Claudio Amato Rocco Damiano Andrea Salonia Riccardo Autorino Alessandro Izzo Francesco Passaro Sisto Perdonà |
| author_sort | Simone Cilio |
| collection | DOAJ |
| description | Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE) vs. glansectomy with urethral glanduloplasty. Methods: Complete data from 60 patients with PC were analyzed at our institution from 2017 to 2022. Patients were asked for personal habits and clinical features. PC was assessed with a clinical visit and imaging techniques. At the outpatient follow-up visit or phone call, all patients compiled the Changes in Sexual Function Questionnaire (CSFQ) and the International Index of Erectile Function in its short 5-item form (IIEF-5). Erectile function (EF) impairment was categorized using Cappelleri’s criteria. Results: Overall, 34 patients with PC confined to the glans (c ≤ T2N0) were included. Of those, 12 underwent WLE and 22 underwent glansectomy with urethral glanduloplasty. Using multivariable logistic regression, glansectomy (OR: 3.49) and diabetes (OR: 2.33) were associated with erectile disfunction (IEEF < 22). Meanwhile, using multivariable linear regression analysis, younger patients (Coeff: −2.41) and those that underwent glansectomy (Coeff: −7.5) had a higher risk of sexual function impairment, according to the CSFQ. Conclusions: Patients with PC ≤ T2N0 that underwent WLE have better outcomes in terms of sexual functioning than the patients who underwent glansectomy and uretheral gladuloplasty. Further research is needed to clarify the outcomes of penile-sparing surgery, to inform patients in pre-surgical counseling more comprehensively, and to meet their post-operative expectations more effectively. |
| first_indexed | 2024-03-08T20:52:13Z |
| format | Article |
| id | doaj.art-db453eb20373493595e0d19a95c44618 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-08T20:52:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-db453eb20373493595e0d19a95c446182023-12-22T14:02:27ZengMDPI AGCurrent Oncology1198-00521718-77292023-12-013012105011050810.3390/curroncol30120765Sexual Outcomes after Conservative Management for Patients with Localized Penile CancerSimone Cilio0Antonio Tufano1Gabriele Pezone2Pierluigi Alvino3Gianluca Spena4Savio Domenico Pandolfo5Paola Del Prete6Claudio Amato7Rocco Damiano8Andrea Salonia9Riccardo Autorino10Alessandro Izzo11Francesco Passaro12Sisto Perdonà13Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Maternal-Infant and Urological Sciences, Policlinico Umberto I Hospital, “Sapienza” Rome University, 00161 Rome, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, ItalyScientific Directorate, Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyDipartimento di Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyUrology Unit, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyUnit of Urology/Division of Experimental Oncology, URI, IRCCS Ospedale San Raffaele, 20141 Milan, ItalyDepartment of Urology, Rush University Medical Center, Chicago, IL 60637, USAUro-Gynecological Department, Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyUrology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, ItalyUro-Gynecological Department, Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via M. Semmola, 80131 Naples, ItalyBackground: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE) vs. glansectomy with urethral glanduloplasty. Methods: Complete data from 60 patients with PC were analyzed at our institution from 2017 to 2022. Patients were asked for personal habits and clinical features. PC was assessed with a clinical visit and imaging techniques. At the outpatient follow-up visit or phone call, all patients compiled the Changes in Sexual Function Questionnaire (CSFQ) and the International Index of Erectile Function in its short 5-item form (IIEF-5). Erectile function (EF) impairment was categorized using Cappelleri’s criteria. Results: Overall, 34 patients with PC confined to the glans (c ≤ T2N0) were included. Of those, 12 underwent WLE and 22 underwent glansectomy with urethral glanduloplasty. Using multivariable logistic regression, glansectomy (OR: 3.49) and diabetes (OR: 2.33) were associated with erectile disfunction (IEEF < 22). Meanwhile, using multivariable linear regression analysis, younger patients (Coeff: −2.41) and those that underwent glansectomy (Coeff: −7.5) had a higher risk of sexual function impairment, according to the CSFQ. Conclusions: Patients with PC ≤ T2N0 that underwent WLE have better outcomes in terms of sexual functioning than the patients who underwent glansectomy and uretheral gladuloplasty. Further research is needed to clarify the outcomes of penile-sparing surgery, to inform patients in pre-surgical counseling more comprehensively, and to meet their post-operative expectations more effectively.https://www.mdpi.com/1718-7729/30/12/765penile cancerpenile neoplasmlocalized penile cancerpenile-sparing surgeryglansectomywide local resection |
| spellingShingle | Simone Cilio Antonio Tufano Gabriele Pezone Pierluigi Alvino Gianluca Spena Savio Domenico Pandolfo Paola Del Prete Claudio Amato Rocco Damiano Andrea Salonia Riccardo Autorino Alessandro Izzo Francesco Passaro Sisto Perdonà Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer Current Oncology penile cancer penile neoplasm localized penile cancer penile-sparing surgery glansectomy wide local resection |
| title | Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer |
| title_full | Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer |
| title_fullStr | Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer |
| title_full_unstemmed | Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer |
| title_short | Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer |
| title_sort | sexual outcomes after conservative management for patients with localized penile cancer |
| topic | penile cancer penile neoplasm localized penile cancer penile-sparing surgery glansectomy wide local resection |
| url | https://www.mdpi.com/1718-7729/30/12/765 |
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