Clinical and Subtypes of Breast Cancer in Indonesia
Background: Breast cancer is still a global public health problem, especially in women and is the second leading cause of death after lung cancer. Indonesia is a country with a high incidence of breast among women. Methods: This study used a retrospective study of breast cancer patients registered...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
West Asia Organization for Cancer Prevention
2020-12-01
|
| Series: | Asian Pacific Journal of Cancer Care |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcc/article/view/550 |
| _version_ | 1797344313434177536 |
|---|---|
| author | I Ketut Widiana Hendry Irawan |
| author_facet | I Ketut Widiana Hendry Irawan |
| author_sort | I Ketut Widiana |
| collection | DOAJ |
| description | Background: Breast cancer is still a global public health problem, especially in women and is the second leading cause of death after lung cancer. Indonesia is a country with a high incidence of breast among women.
Methods: This study used a retrospective study of breast cancer patients registered at Division of Surgical Oncology in Indonesia. Information about demographic, clinical and pathological characteristics of patients for a period of 5 years (2014 to 2020) were collected and described.
Results: Information for 1260 cases of breast cancer who underwent IHC examination with an average age of 53.73 years of patients, with the most age above 50 years (63.6%) were collected. On IHC examination, 58.6% positive estrogen receptors were found, positive progesterone receptors were 55.4%, Her2 was positive 37.7% and high Ki67 protein was 56.9%. The most common breast cancer subtypes were luminal B (43.2%), followed by luminal A (21.7%), TNBC (18.1%), and Her2 (17%), with the highest stages being IIIB (31.7%).
Conclusions: The breast cancer was presented at higher stage, with more cases with estrogen or progesterone receptors are positive with low frequency of Her2 positivity and high in Ki67 protein expression. |
| first_indexed | 2024-03-08T11:00:35Z |
| format | Article |
| id | doaj.art-db458cdde6b54c80a52442b95b4d9563 |
| institution | Directory Open Access Journal |
| issn | 2588-3682 |
| language | English |
| last_indexed | 2024-03-08T11:00:35Z |
| publishDate | 2020-12-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Care |
| spelling | doaj.art-db458cdde6b54c80a52442b95b4d95632024-01-26T16:05:03ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Care2588-36822020-12-015428128510.31557/apjcc.2020.5.4.281-285550Clinical and Subtypes of Breast Cancer in IndonesiaI Ketut Widiana0Hendry Irawan1Surgical Oncology Division, Department of Surgery, Medical Faculty Udayana University, Sanglah General Hospital DenpasarSurgical Oncology Division, Department of Surgery, Medical Faculty Udayana University, Sanglah General Hospital DenpasarBackground: Breast cancer is still a global public health problem, especially in women and is the second leading cause of death after lung cancer. Indonesia is a country with a high incidence of breast among women. Methods: This study used a retrospective study of breast cancer patients registered at Division of Surgical Oncology in Indonesia. Information about demographic, clinical and pathological characteristics of patients for a period of 5 years (2014 to 2020) were collected and described. Results: Information for 1260 cases of breast cancer who underwent IHC examination with an average age of 53.73 years of patients, with the most age above 50 years (63.6%) were collected. On IHC examination, 58.6% positive estrogen receptors were found, positive progesterone receptors were 55.4%, Her2 was positive 37.7% and high Ki67 protein was 56.9%. The most common breast cancer subtypes were luminal B (43.2%), followed by luminal A (21.7%), TNBC (18.1%), and Her2 (17%), with the highest stages being IIIB (31.7%). Conclusions: The breast cancer was presented at higher stage, with more cases with estrogen or progesterone receptors are positive with low frequency of Her2 positivity and high in Ki67 protein expression.http://www.waocp.com/journal/index.php/apjcc/article/view/550breast cancerindonesiaimmunohistochemistrysubtypesstaging |
| spellingShingle | I Ketut Widiana Hendry Irawan Clinical and Subtypes of Breast Cancer in Indonesia Asian Pacific Journal of Cancer Care breast cancer indonesia immunohistochemistry subtypes staging |
| title | Clinical and Subtypes of Breast Cancer in Indonesia |
| title_full | Clinical and Subtypes of Breast Cancer in Indonesia |
| title_fullStr | Clinical and Subtypes of Breast Cancer in Indonesia |
| title_full_unstemmed | Clinical and Subtypes of Breast Cancer in Indonesia |
| title_short | Clinical and Subtypes of Breast Cancer in Indonesia |
| title_sort | clinical and subtypes of breast cancer in indonesia |
| topic | breast cancer indonesia immunohistochemistry subtypes staging |
| url | http://www.waocp.com/journal/index.php/apjcc/article/view/550 |
| work_keys_str_mv | AT iketutwidiana clinicalandsubtypesofbreastcancerinindonesia AT hendryirawan clinicalandsubtypesofbreastcancerinindonesia |